Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system
Abstract Background To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, and its association with hemodynamics and metabolic parameters. Methods Methods: Male Wistar rats were divided into control (Co...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-021-00795-6 |
| _version_ | 1818618516759117824 |
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| author | Paula L. Cruz Ivana C. Moraes-Silva Amanda A. Ribeiro Jacqueline F. Machi Marcelo Dantas Tavares de Melo Fernando dos Santos Maikon Barbosa da Silva Celia Maria Cassaro Strunz Elia Garcia Caldini Maria-Claudia Irigoyen |
| author_facet | Paula L. Cruz Ivana C. Moraes-Silva Amanda A. Ribeiro Jacqueline F. Machi Marcelo Dantas Tavares de Melo Fernando dos Santos Maikon Barbosa da Silva Celia Maria Cassaro Strunz Elia Garcia Caldini Maria-Claudia Irigoyen |
| author_sort | Paula L. Cruz |
| collection | DOAJ |
| description | Abstract Background To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, and its association with hemodynamics and metabolic parameters. Methods Methods: Male Wistar rats were divided into control (Cont) and STZ-induced diabetes (Diab). Half of the rats from each group received a single dose of nicotinamide (100 mg/Kg) before STZ injection (Cont+NicA and Diab+NicA). All groups were followed-up for 5 weeks. Results Body weight loss of more than 40% was observed in Diab throughout the period (Diab: 271.00 ± 12.74 g; Diab+NicA: 344.62 ± 17.82). Increased glycemia was seen in Diab rats (541.28 ± 18.68 mg/dl) while Diab+NicA group had a slight decrease (440.87 ± 20.96 mg/dl). However, insulin resistance was observed only in Diab. In relation to Cont, heart rate, mean blood pressure and diastolic function were reduced when compared to Diab, together with parasympathetic modulation and baroreflex sensitivity. All of these parameters were improved in Diab+NicA when compared to Diab. Improved baroreflex sensitivity and parasympathetic modulation were correlated with glycemia, insulin resistance, and body weight mass. Additionally, Diab+NicA group increased survival rate. Conclusions Results suggest that the association of nicotinamide in STZ-induced diabetic rats prevents most of the expected derangements mainly by preserving parasympathetic and baroreflex parameters. |
| first_indexed | 2024-12-16T17:22:50Z |
| format | Article |
| id | doaj.art-8ed792183dae473a9e2e3e1460af1081 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-16T17:22:50Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-8ed792183dae473a9e2e3e1460af10812022-12-21T22:23:08ZengBMCBMC Endocrine Disorders1472-68232021-06-0121111010.1186/s12902-021-00795-6Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous systemPaula L. Cruz0Ivana C. Moraes-Silva1Amanda A. Ribeiro2Jacqueline F. Machi3Marcelo Dantas Tavares de Melo4Fernando dos Santos5Maikon Barbosa da Silva6Celia Maria Cassaro Strunz7Elia Garcia Caldini8Maria-Claudia Irigoyen9Heart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolDepartment of Pathology, University of São Paulo Medical SchoolHeart Institute (InCor), University of São Paulo Medical SchoolAbstract Background To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, and its association with hemodynamics and metabolic parameters. Methods Methods: Male Wistar rats were divided into control (Cont) and STZ-induced diabetes (Diab). Half of the rats from each group received a single dose of nicotinamide (100 mg/Kg) before STZ injection (Cont+NicA and Diab+NicA). All groups were followed-up for 5 weeks. Results Body weight loss of more than 40% was observed in Diab throughout the period (Diab: 271.00 ± 12.74 g; Diab+NicA: 344.62 ± 17.82). Increased glycemia was seen in Diab rats (541.28 ± 18.68 mg/dl) while Diab+NicA group had a slight decrease (440.87 ± 20.96 mg/dl). However, insulin resistance was observed only in Diab. In relation to Cont, heart rate, mean blood pressure and diastolic function were reduced when compared to Diab, together with parasympathetic modulation and baroreflex sensitivity. All of these parameters were improved in Diab+NicA when compared to Diab. Improved baroreflex sensitivity and parasympathetic modulation were correlated with glycemia, insulin resistance, and body weight mass. Additionally, Diab+NicA group increased survival rate. Conclusions Results suggest that the association of nicotinamide in STZ-induced diabetic rats prevents most of the expected derangements mainly by preserving parasympathetic and baroreflex parameters.https://doi.org/10.1186/s12902-021-00795-6NicotinamideDiabetesAutonomic nervous system |
| spellingShingle | Paula L. Cruz Ivana C. Moraes-Silva Amanda A. Ribeiro Jacqueline F. Machi Marcelo Dantas Tavares de Melo Fernando dos Santos Maikon Barbosa da Silva Celia Maria Cassaro Strunz Elia Garcia Caldini Maria-Claudia Irigoyen Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system BMC Endocrine Disorders Nicotinamide Diabetes Autonomic nervous system |
| title | Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system |
| title_full | Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system |
| title_fullStr | Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system |
| title_full_unstemmed | Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system |
| title_short | Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system |
| title_sort | nicotinamide attenuates streptozotocin induced diabetes complications and increases survival rate in rats role of autonomic nervous system |
| topic | Nicotinamide Diabetes Autonomic nervous system |
| url | https://doi.org/10.1186/s12902-021-00795-6 |
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