Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2
Precision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient׳s individual pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-07-01
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| Series: | Acta Pharmaceutica Sinica B |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383518309158 |
| _version_ | 1818943330787000320 |
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| author | Liming Chen Jose E. Manautou Theodore P. Rasmussen Xiao-bo Zhong |
| author_facet | Liming Chen Jose E. Manautou Theodore P. Rasmussen Xiao-bo Zhong |
| author_sort | Liming Chen |
| collection | DOAJ |
| description | Precision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient׳s individual parameters that affect drug transporter action can be used to develop a precision medicine guidance, due to the fact that therapeutic efficacy and adverse reactions of drugs can both be affected by expression and function of drug transporters on the cell membrane surface. The purpose of this review is to summarize unique characteristics of human breast cancer resistant protein (BCRP) and the genetic variability in the BCRP encoded gene ABCG2 in the development of precision medicine. Inter-individual variability of BCRP/ABCG2 can impact choices and outcomes of drug treatment for several diseases, including cancer chemotherapy. Several factors have been implicated in expression and function of BCRP, including genetic, epigenetic, physiologic, pathologic, and environmental factors. Understanding the roles of these factors in controlling expression and function of BCRP is critical for the development of precision medicine based on BCRP-mediated drug transport. Keywords: BCRP, Epigenetics, Gene polymorphisms, Physiologic factors, Precision medicine |
| first_indexed | 2024-12-20T07:25:37Z |
| format | Article |
| id | doaj.art-8ed9d8c408e441bbb1b778bf67a2bcf7 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-20T07:25:37Z |
| publishDate | 2019-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-8ed9d8c408e441bbb1b778bf67a2bcf72022-12-21T19:48:33ZengElsevierActa Pharmaceutica Sinica B2211-38352019-07-0194659674Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2Liming Chen0Jose E. Manautou1Theodore P. Rasmussen2Xiao-bo Zhong3Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USACorresponding author. Tel.: +1 860 4863697.; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USAPrecision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient׳s individual parameters that affect drug transporter action can be used to develop a precision medicine guidance, due to the fact that therapeutic efficacy and adverse reactions of drugs can both be affected by expression and function of drug transporters on the cell membrane surface. The purpose of this review is to summarize unique characteristics of human breast cancer resistant protein (BCRP) and the genetic variability in the BCRP encoded gene ABCG2 in the development of precision medicine. Inter-individual variability of BCRP/ABCG2 can impact choices and outcomes of drug treatment for several diseases, including cancer chemotherapy. Several factors have been implicated in expression and function of BCRP, including genetic, epigenetic, physiologic, pathologic, and environmental factors. Understanding the roles of these factors in controlling expression and function of BCRP is critical for the development of precision medicine based on BCRP-mediated drug transport. Keywords: BCRP, Epigenetics, Gene polymorphisms, Physiologic factors, Precision medicinehttp://www.sciencedirect.com/science/article/pii/S2211383518309158 |
| spellingShingle | Liming Chen Jose E. Manautou Theodore P. Rasmussen Xiao-bo Zhong Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 Acta Pharmaceutica Sinica B |
| title | Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 |
| title_full | Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 |
| title_fullStr | Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 |
| title_full_unstemmed | Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 |
| title_short | Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2 |
| title_sort | development of precision medicine approaches based on inter individual variability of bcrp abcg2 |
| url | http://www.sciencedirect.com/science/article/pii/S2211383518309158 |
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