Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy
Phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), combined with novel all-in-one light-responsive nanocomposites have recently emerged as new therapeutic modalities for the treatment of cancer. Herein, we developed novel all-in-one triphenylphosphonium-functionalized...
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MDPI AG
2024-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/2/284 |
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| author | Ara Joe Hyo-Won Han Yu-Ra Lim Panchanathan Manivasagan Eue-Soon Jang |
| author_facet | Ara Joe Hyo-Won Han Yu-Ra Lim Panchanathan Manivasagan Eue-Soon Jang |
| author_sort | Ara Joe |
| collection | DOAJ |
| description | Phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), combined with novel all-in-one light-responsive nanocomposites have recently emerged as new therapeutic modalities for the treatment of cancer. Herein, we developed novel all-in-one triphenylphosphonium-functionalized gold nanorod/zinc oxide core–shell nanocomposites (CTPP-GNR@ZnO) for mitochondrial-targeted PTT/PDT owing to their good biocompatibility, tunable and high optical absorption, photothermal conversion efficiency, highest reactive oxygen species (ROS) generation, and high mitochondrial-targeting capability. Under laser irradiation of 780 nm, the CTPP-GNR@ZnO core–shell nanocomposites effectively produced heat in addition to generating ROS to induce cell death, implying a synergistic effect of mild PTT and PDT in combating cancer. Notably, the in vitro PTT/PDT effect of CTPP-GNR@ZnO core–shell nanocomposites exhibited effective cell ablation (95%) and induced significant intracellular ROS after the 780 nm laser irradiation for 50 min, indicating that CTPP in CTPP-GNR@ZnO core–shell nanocomposites can specifically target the mitochondria of CT-26 cells, as well as generate heat and ROS to completely kill cancer cells. Overall, this light-responsive nanocomposite-based phototherapy provides a new approach for cancer synergistic therapy. |
| first_indexed | 2024-03-07T22:18:04Z |
| format | Article |
| id | doaj.art-8ede8327733f424d80726ba511623f74 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:18:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8ede8327733f424d80726ba511623f742024-02-23T15:31:18ZengMDPI AGPharmaceutics1999-49232024-02-0116228410.3390/pharmaceutics16020284Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted PhototherapyAra Joe0Hyo-Won Han1Yu-Ra Lim2Panchanathan Manivasagan3Eue-Soon Jang4Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701, Gyeongbuk, Republic of KoreaDepartment of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701, Gyeongbuk, Republic of KoreaDepartment of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701, Gyeongbuk, Republic of KoreaDepartment of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701, Gyeongbuk, Republic of KoreaDepartment of Applied Chemistry, Kumoh National Institute of Technology, Gumi 730-701, Gyeongbuk, Republic of KoreaPhototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), combined with novel all-in-one light-responsive nanocomposites have recently emerged as new therapeutic modalities for the treatment of cancer. Herein, we developed novel all-in-one triphenylphosphonium-functionalized gold nanorod/zinc oxide core–shell nanocomposites (CTPP-GNR@ZnO) for mitochondrial-targeted PTT/PDT owing to their good biocompatibility, tunable and high optical absorption, photothermal conversion efficiency, highest reactive oxygen species (ROS) generation, and high mitochondrial-targeting capability. Under laser irradiation of 780 nm, the CTPP-GNR@ZnO core–shell nanocomposites effectively produced heat in addition to generating ROS to induce cell death, implying a synergistic effect of mild PTT and PDT in combating cancer. Notably, the in vitro PTT/PDT effect of CTPP-GNR@ZnO core–shell nanocomposites exhibited effective cell ablation (95%) and induced significant intracellular ROS after the 780 nm laser irradiation for 50 min, indicating that CTPP in CTPP-GNR@ZnO core–shell nanocomposites can specifically target the mitochondria of CT-26 cells, as well as generate heat and ROS to completely kill cancer cells. Overall, this light-responsive nanocomposite-based phototherapy provides a new approach for cancer synergistic therapy.https://www.mdpi.com/1999-4923/16/2/284gold nanorodszinc oxidetriphenylphosphoniumcancerphototherapy |
| spellingShingle | Ara Joe Hyo-Won Han Yu-Ra Lim Panchanathan Manivasagan Eue-Soon Jang Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy Pharmaceutics gold nanorods zinc oxide triphenylphosphonium cancer phototherapy |
| title | Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy |
| title_full | Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy |
| title_fullStr | Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy |
| title_full_unstemmed | Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy |
| title_short | Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy |
| title_sort | triphenylphosphonium functionalized gold nanorod zinc oxide core shell nanocomposites for mitochondrial targeted phototherapy |
| topic | gold nanorods zinc oxide triphenylphosphonium cancer phototherapy |
| url | https://www.mdpi.com/1999-4923/16/2/284 |
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