Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism
The extracellular matrix (ECM) niche plays a critical role in determining cellular behavior during bone development including the differentiation and lineage allocation of skeletal progenitor cells to chondrocytes, osteoblasts, or marrow adipocytes. As the major ECM component in mineralized tissues,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1181817/full |
| _version_ | 1826807880521613312 |
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| author | Renny T. Franceschi Shawn A. Hallett Chunxi Ge |
| author_facet | Renny T. Franceschi Shawn A. Hallett Chunxi Ge |
| author_sort | Renny T. Franceschi |
| collection | DOAJ |
| description | The extracellular matrix (ECM) niche plays a critical role in determining cellular behavior during bone development including the differentiation and lineage allocation of skeletal progenitor cells to chondrocytes, osteoblasts, or marrow adipocytes. As the major ECM component in mineralized tissues, collagen has instructive as well as structural roles during bone development and is required for bone cell differentiation. Cells sense their extracellular environment using specific cell surface receptors. For many years, specific β1 integrins were considered the main collagen receptors in bone, but, more recently, the important role of a second, more primordial collagen receptor family, the discoidin domain receptors, has become apparent. This review will specifically focus on the roles of discoidin domain receptors in mineralized tissue development as well as related functions in abnormal bone formation, regeneration and metabolism. |
| first_indexed | 2024-04-09T13:11:24Z |
| format | Article |
| id | doaj.art-8edf7027ddf345dea85d46fdb54977e9 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2025-02-16T00:39:12Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-8edf7027ddf345dea85d46fdb54977e92025-02-11T10:45:42ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152023-05-01410.3389/fdmed.2023.11818171181817Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolismRenny T. FranceschiShawn A. HallettChunxi GeThe extracellular matrix (ECM) niche plays a critical role in determining cellular behavior during bone development including the differentiation and lineage allocation of skeletal progenitor cells to chondrocytes, osteoblasts, or marrow adipocytes. As the major ECM component in mineralized tissues, collagen has instructive as well as structural roles during bone development and is required for bone cell differentiation. Cells sense their extracellular environment using specific cell surface receptors. For many years, specific β1 integrins were considered the main collagen receptors in bone, but, more recently, the important role of a second, more primordial collagen receptor family, the discoidin domain receptors, has become apparent. This review will specifically focus on the roles of discoidin domain receptors in mineralized tissue development as well as related functions in abnormal bone formation, regeneration and metabolism.https://www.frontiersin.org/articles/10.3389/fdmed.2023.1181817/fullextracellular matrixcollagen receptordifferentiationstem cellbonecartilage |
| spellingShingle | Renny T. Franceschi Shawn A. Hallett Chunxi Ge Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism Frontiers in Dental Medicine extracellular matrix collagen receptor differentiation stem cell bone cartilage |
| title | Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism |
| title_full | Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism |
| title_fullStr | Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism |
| title_full_unstemmed | Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism |
| title_short | Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism |
| title_sort | discoidin domain receptors an ancient family of collagen receptors has major roles in bone development regeneration and metabolism |
| topic | extracellular matrix collagen receptor differentiation stem cell bone cartilage |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1181817/full |
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