Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, bu...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1363415/full |
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| author | Ning Tang Yan Wang Jiarui Miao Yang Zhao Yue Cao Wentao Sun Jingke Zhang Hua Sui Bing Li |
| author_facet | Ning Tang Yan Wang Jiarui Miao Yang Zhao Yue Cao Wentao Sun Jingke Zhang Hua Sui Bing Li |
| author_sort | Ning Tang |
| collection | DOAJ |
| description | Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological mechanism is systematically evaluated by the combined method of network pharmacology and molecular docking. PharmMapper and SwissTargetPrediction predicted 331 potential Tan-IIA-related targets, and 1,152 potential neuroblastoma-related targets were obtained from GeneCards, DisGeNET, DrugBank, OMIM and Therapeutic Target databases (TTD), 107 common targets for Tan-IIA and neuroblastoma. Through gene ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomesa (KEGG) pathway enrichment, protein-protein interaction (PPI) network and cytoHubba plug-in, 10 related signal pathways (Pathways in cancer, PI3K-Akt signaling pathway, Prostate cancer, etc.) and 10 hub genes were identified. The results of molecular docking showed that Tan-IIA could interact with 10 targets: GRB2, SRC, EGFR, PTPN1, ESR1, IGF1, MAPK1, PIK3R1, AKT1 and IGF1R. This study analyzed the related pathways and targets of Tan-IIA in the treatment of human neuroblastoma, as well as the potential anticancer and anti-tumor targets and related signaling pathways of Tan-IIA, which provides a reference for us to find and explore effective drugs for the treatment of human neuroblastoma. |
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| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-25T00:43:12Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-8ee0e7150c5a44579f5b5ef77c6bcb262024-03-12T07:41:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-03-011510.3389/fphar.2024.13634151363415Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking TechnologyNing Tang0Yan Wang1Jiarui Miao2Yang Zhao3Yue Cao4Wentao Sun5Jingke Zhang6Hua Sui7Bing Li8Department of Integrative Medicine, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Integrative Medicine, Dalian Medical University, Dalian, ChinaDepartment of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Integrative Medicine, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Integrative Medicine, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Integrative Medicine, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaDepartment of Integrative Medicine, Dalian Medical University, Dalian, ChinaDepartment of Integrative Medicine, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, ChinaTanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological mechanism is systematically evaluated by the combined method of network pharmacology and molecular docking. PharmMapper and SwissTargetPrediction predicted 331 potential Tan-IIA-related targets, and 1,152 potential neuroblastoma-related targets were obtained from GeneCards, DisGeNET, DrugBank, OMIM and Therapeutic Target databases (TTD), 107 common targets for Tan-IIA and neuroblastoma. Through gene ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomesa (KEGG) pathway enrichment, protein-protein interaction (PPI) network and cytoHubba plug-in, 10 related signal pathways (Pathways in cancer, PI3K-Akt signaling pathway, Prostate cancer, etc.) and 10 hub genes were identified. The results of molecular docking showed that Tan-IIA could interact with 10 targets: GRB2, SRC, EGFR, PTPN1, ESR1, IGF1, MAPK1, PIK3R1, AKT1 and IGF1R. This study analyzed the related pathways and targets of Tan-IIA in the treatment of human neuroblastoma, as well as the potential anticancer and anti-tumor targets and related signaling pathways of Tan-IIA, which provides a reference for us to find and explore effective drugs for the treatment of human neuroblastoma.https://www.frontiersin.org/articles/10.3389/fphar.2024.1363415/fullneuroblastomatanshinone IIAnetwork pharmacologymolecular dockinggene ontology |
| spellingShingle | Ning Tang Yan Wang Jiarui Miao Yang Zhao Yue Cao Wentao Sun Jingke Zhang Hua Sui Bing Li Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology Frontiers in Pharmacology neuroblastoma tanshinone IIA network pharmacology molecular docking gene ontology |
| title | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology |
| title_full | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology |
| title_fullStr | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology |
| title_full_unstemmed | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology |
| title_short | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology |
| title_sort | potential pharmacological mechanisms of tanshinone iia in the treatment of human neuroblastoma based on network pharmacological and molecular docking technology |
| topic | neuroblastoma tanshinone IIA network pharmacology molecular docking gene ontology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1363415/full |
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