Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model

Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model

Abstract Background Infants with congenital heart defects (CHD) are at risk for white matter brain injury. This novel rat pup model characterizes the systemic effects of intravasal cell-free hemoglobin and hyperoxia, hypothesizing that immature endogenous scavenging systems relate to increased vulne...

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Bibliographic Details
Main Authors: Åsa Jungner, Suvi Vallius, Matteo Bruschettini, Olga Romantsik, Magnus Gram, David Ley
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:Intensive Care Medicine Experimental
Subjects:
Congenital heart disease
Cardiopulmonary bypass
Cell-free hemoglobin
Hyperoxia
Neonate
Animal model
Online Access:http://link.springer.com/article/10.1186/s40635-017-0153-2

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