Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP

Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP

New therapeutic strategies are needed for cutaneous T-cell lymphoma (CTCL), and the plant extract ingenol mebutate (PEP005) may be considered. PEP005 has been approved for actinic keratosis, and proapoptotic activities were described in different cancer cells. Here, we aimed to investigate its effic...

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Bibliographic Details
Main Authors: Uly Sumarni, Ulrich Reidel, Jürgen Eberle
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
cutaneous T-cell lymphoma (CTCL)
PEP005
PKC-delta
apoptosis
caspases
ROS
Online Access:https://www.mdpi.com/2073-4409/10/5/987

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