Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors
ObjectiveOur study represents the first meta-analysis conducted to evaluate the prognostic utility of the baseline prognostic nutritional index (PNI) in patients with gastrointestinal cancer (GIC) who received immune checkpoint inhibitor (ICI) therapy.MethodsWe searched PubMed, the Cochrane Library,...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219929/full |
| _version_ | 1797775298152890368 |
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| author | Lilong Zhang Lilong Zhang Wangbin Ma Wangbin Ma Zhendong Qiu Zhendong Qiu Tianrui Kuang Tianrui Kuang Kunpeng Wang Kunpeng Wang Baohong Hu Baohong Hu Weixing Wang Weixing Wang |
| author_facet | Lilong Zhang Lilong Zhang Wangbin Ma Wangbin Ma Zhendong Qiu Zhendong Qiu Tianrui Kuang Tianrui Kuang Kunpeng Wang Kunpeng Wang Baohong Hu Baohong Hu Weixing Wang Weixing Wang |
| author_sort | Lilong Zhang |
| collection | DOAJ |
| description | ObjectiveOur study represents the first meta-analysis conducted to evaluate the prognostic utility of the baseline prognostic nutritional index (PNI) in patients with gastrointestinal cancer (GIC) who received immune checkpoint inhibitor (ICI) therapy.MethodsWe searched PubMed, the Cochrane Library, EMBASE, and Google Scholar until April 23, 2023, to obtain relevant articles for this study. Our analysis examined several clinical outcomes, including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).ResultsIn this analysis, a total of 17 articles with 2883 patients were included. Our pooled results indicated that patients with high PNI levels had longer OS (HR: 0.530, 95% CI: 0.456-0.616, p < 0.001) and PFS (HR: 0.740, 95% CI: 0.649-0.844, p < 0.001), as well as higher ORR (OR: 1.622, 95% CI: 1.251-2.103, p < 0.004) and DCR (OR: 1.846, 95% CI: 1.428-2.388, p < 0.001). Subgroup analysis showed that PNI cutoff values of 40 to 45 showed greater predictive potential. Subgroup analysis also confirmed that the above findings still hold true in patients with esophageal cancer, gastric cancer, and hepatocellular carcinomas.ConclusionThe PNI were reliable predictors of outcomes in GIC patients treated with ICIs. |
| first_indexed | 2024-03-12T22:33:40Z |
| format | Article |
| id | doaj.art-8ee74cb7423741cdac98eb1f024016de |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T22:33:40Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8ee74cb7423741cdac98eb1f024016de2023-07-21T14:28:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12199291219929Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitorsLilong Zhang0Lilong Zhang1Wangbin Ma2Wangbin Ma3Zhendong Qiu4Zhendong Qiu5Tianrui Kuang6Tianrui Kuang7Kunpeng Wang8Kunpeng Wang9Baohong Hu10Baohong Hu11Weixing Wang12Weixing Wang13Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaKey Laboratory of Hubei Province for Digestive System Disease, Wuhan, ChinaObjectiveOur study represents the first meta-analysis conducted to evaluate the prognostic utility of the baseline prognostic nutritional index (PNI) in patients with gastrointestinal cancer (GIC) who received immune checkpoint inhibitor (ICI) therapy.MethodsWe searched PubMed, the Cochrane Library, EMBASE, and Google Scholar until April 23, 2023, to obtain relevant articles for this study. Our analysis examined several clinical outcomes, including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).ResultsIn this analysis, a total of 17 articles with 2883 patients were included. Our pooled results indicated that patients with high PNI levels had longer OS (HR: 0.530, 95% CI: 0.456-0.616, p < 0.001) and PFS (HR: 0.740, 95% CI: 0.649-0.844, p < 0.001), as well as higher ORR (OR: 1.622, 95% CI: 1.251-2.103, p < 0.004) and DCR (OR: 1.846, 95% CI: 1.428-2.388, p < 0.001). Subgroup analysis showed that PNI cutoff values of 40 to 45 showed greater predictive potential. Subgroup analysis also confirmed that the above findings still hold true in patients with esophageal cancer, gastric cancer, and hepatocellular carcinomas.ConclusionThe PNI were reliable predictors of outcomes in GIC patients treated with ICIs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219929/fullprognostic nutrition indeximmune checkpoint inhibitorsgastrointestinal cancersesophageal cancergastric cancerhepatocellular carcinoma |
| spellingShingle | Lilong Zhang Lilong Zhang Wangbin Ma Wangbin Ma Zhendong Qiu Zhendong Qiu Tianrui Kuang Tianrui Kuang Kunpeng Wang Kunpeng Wang Baohong Hu Baohong Hu Weixing Wang Weixing Wang Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors Frontiers in Immunology prognostic nutrition index immune checkpoint inhibitors gastrointestinal cancers esophageal cancer gastric cancer hepatocellular carcinoma |
| title | Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| title_full | Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| title_fullStr | Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| title_full_unstemmed | Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| title_short | Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| title_sort | prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors |
| topic | prognostic nutrition index immune checkpoint inhibitors gastrointestinal cancers esophageal cancer gastric cancer hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219929/full |
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