Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications

Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits. In order to establish an assay to identify protein-protein-in...

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Bibliographic Details
Main Authors: Christian Nienberg, Anika Retterath, Kira-Sophie Becher, Thorsten Saenger, Henning D. Mootz, Joachim Jose
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Pharmaceuticals
Subjects:
CK2
kinase
Autodisplay
click chemistry
unnatural amino acid
bioorthogonal
labeling
drug discovery
protein-protein interaction
Online Access:http://www.mdpi.com/1424-8247/9/3/36

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