| Summary: | Introduction
Contradictory results regarding the safety of human papillomavirus (HPV)
vaccination during pregnancy have been obtained, which has cast doubt on the use of
this method. This review and meta-analysis were conducted to evaluate the safety of HPV
vaccination during pregnancy.
Methods
Complying with the inclusion and exclusion criteria, we searched Web of
Science, Scopus, Medline, EMBASE, PubMed and Google Scholar databases for articles
published in the past decade using the following keywords: ‘papilloma human virus’, ‘HPV
vaccine’, ‘pregnancy’ and ‘safety and prevention’. The minimum report quality of the
articles was 16 based on the STROBE checklist.
Results
Seven articles were included in the study, three of which were included in the
meta-analysis, and the rest were reviewed systematically. The results of the meta-analysis
showed that vaccination against HPV during pregnancy or around this period does not
increase the risk of miscarriage (RR=2.01; 95% CI: 0.66–6.13) and stillbirth (RR=2.02:
95% CI: 0.65–6.27). No significant difference between miscarriage and stillbirth was
observed in women vaccinated against HPV versus those not vaccinated.
Conclusions
The study of 1380424 individuals showed that HPV vaccination during
pregnancy is better postponed until after this period. However, no significant evidence was
found to indicate that vaccination was dangerous and unsafe during pregnancy. Further
studies are needed to draw a more definitive conclusion.
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