Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review
Introduction Contradictory results regarding the safety of human papillomavirus (HPV) vaccination during pregnancy have been obtained, which has cast doubt on the use of this method. This review and meta-analysis were conducted to evaluate the safety of HPV vaccination during pregnancy. Methods Com...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-04-01
|
| Series: | European Journal of Midwifery |
| Subjects: | |
| Online Access: | http://www.europeanjournalofmidwifery.eu/Can-human-papillomavirus-vaccination-during-pregnancy-result-in-miscarriage-and-stillbirth,161793,0,2.html |
| _version_ | 1797737655910268928 |
|---|---|
| author | Rana Dousti Leila Allahqoli Asiye Ayar Kocaturk Sevil Hakimi |
| author_facet | Rana Dousti Leila Allahqoli Asiye Ayar Kocaturk Sevil Hakimi |
| author_sort | Rana Dousti |
| collection | DOAJ |
| description | Introduction
Contradictory results regarding the safety of human papillomavirus (HPV)
vaccination during pregnancy have been obtained, which has cast doubt on the use of
this method. This review and meta-analysis were conducted to evaluate the safety of HPV
vaccination during pregnancy.
Methods
Complying with the inclusion and exclusion criteria, we searched Web of
Science, Scopus, Medline, EMBASE, PubMed and Google Scholar databases for articles
published in the past decade using the following keywords: ‘papilloma human virus’, ‘HPV
vaccine’, ‘pregnancy’ and ‘safety and prevention’. The minimum report quality of the
articles was 16 based on the STROBE checklist.
Results
Seven articles were included in the study, three of which were included in the
meta-analysis, and the rest were reviewed systematically. The results of the meta-analysis
showed that vaccination against HPV during pregnancy or around this period does not
increase the risk of miscarriage (RR=2.01; 95% CI: 0.66–6.13) and stillbirth (RR=2.02:
95% CI: 0.65–6.27). No significant difference between miscarriage and stillbirth was
observed in women vaccinated against HPV versus those not vaccinated.
Conclusions
The study of 1380424 individuals showed that HPV vaccination during
pregnancy is better postponed until after this period. However, no significant evidence was
found to indicate that vaccination was dangerous and unsafe during pregnancy. Further
studies are needed to draw a more definitive conclusion. |
| first_indexed | 2024-03-12T13:31:35Z |
| format | Article |
| id | doaj.art-8ee8286d143344ac8fb10e56bf260e73 |
| institution | Directory Open Access Journal |
| issn | 2585-2906 |
| language | English |
| last_indexed | 2024-03-12T13:31:35Z |
| publishDate | 2023-04-01 |
| publisher | European Publishing |
| record_format | Article |
| series | European Journal of Midwifery |
| spelling | doaj.art-8ee8286d143344ac8fb10e56bf260e732023-08-24T10:39:40ZengEuropean PublishingEuropean Journal of Midwifery2585-29062023-04-017April1610.18332/ejm/161793161793Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic reviewRana Dousti0Leila Allahqoli1Asiye Ayar Kocaturk2Sevil Hakimi3https://orcid.org/0000-0002-3164-4867Faculty of Nursing and Midwifery, Tabriz University of Medical Science, Tabriz, IranMidwifery Department, Ministry of Health and Medical Education, Tehran, IranSchool of Health Sciences, Istanbul Medipol University, Istanbul, TurkeyFaculty of Nursing and Midwifery, Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranIntroduction Contradictory results regarding the safety of human papillomavirus (HPV) vaccination during pregnancy have been obtained, which has cast doubt on the use of this method. This review and meta-analysis were conducted to evaluate the safety of HPV vaccination during pregnancy. Methods Complying with the inclusion and exclusion criteria, we searched Web of Science, Scopus, Medline, EMBASE, PubMed and Google Scholar databases for articles published in the past decade using the following keywords: ‘papilloma human virus’, ‘HPV vaccine’, ‘pregnancy’ and ‘safety and prevention’. The minimum report quality of the articles was 16 based on the STROBE checklist. Results Seven articles were included in the study, three of which were included in the meta-analysis, and the rest were reviewed systematically. The results of the meta-analysis showed that vaccination against HPV during pregnancy or around this period does not increase the risk of miscarriage (RR=2.01; 95% CI: 0.66–6.13) and stillbirth (RR=2.02: 95% CI: 0.65–6.27). No significant difference between miscarriage and stillbirth was observed in women vaccinated against HPV versus those not vaccinated. Conclusions The study of 1380424 individuals showed that HPV vaccination during pregnancy is better postponed until after this period. However, no significant evidence was found to indicate that vaccination was dangerous and unsafe during pregnancy. Further studies are needed to draw a more definitive conclusion.http://www.europeanjournalofmidwifery.eu/Can-human-papillomavirus-vaccination-during-pregnancy-result-in-miscarriage-and-stillbirth,161793,0,2.htmlvaccinationhpvpregnancymiscarriagestillbirth |
| spellingShingle | Rana Dousti Leila Allahqoli Asiye Ayar Kocaturk Sevil Hakimi Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review European Journal of Midwifery vaccination hpv pregnancy miscarriage stillbirth |
| title | Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review |
| title_full | Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review |
| title_fullStr | Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review |
| title_full_unstemmed | Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review |
| title_short | Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review |
| title_sort | can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth a meta analysis and systematic review |
| topic | vaccination hpv pregnancy miscarriage stillbirth |
| url | http://www.europeanjournalofmidwifery.eu/Can-human-papillomavirus-vaccination-during-pregnancy-result-in-miscarriage-and-stillbirth,161793,0,2.html |
| work_keys_str_mv | AT ranadousti canhumanpapillomavirusvaccinationduringpregnancyresultinmiscarriageandstillbirthametaanalysisandsystematicreview AT leilaallahqoli canhumanpapillomavirusvaccinationduringpregnancyresultinmiscarriageandstillbirthametaanalysisandsystematicreview AT asiyeayarkocaturk canhumanpapillomavirusvaccinationduringpregnancyresultinmiscarriageandstillbirthametaanalysisandsystematicreview AT sevilhakimi canhumanpapillomavirusvaccinationduringpregnancyresultinmiscarriageandstillbirthametaanalysisandsystematicreview |