One-way or two-way sweet link between theobromine and depression?

Abstract Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the risk of depression, the diagnosis of...

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Main Authors: Rafael Franco, Eva Martínez-Pinilla
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Psychiatry
Online Access:https://doi.org/10.1186/s12888-023-04662-7
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author Rafael Franco
Eva Martínez-Pinilla
author_facet Rafael Franco
Eva Martínez-Pinilla
author_sort Rafael Franco
collection DOAJ
description Abstract Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the risk of depression, the diagnosis of which is not simple to make. Also, it is not easy to assess the amount of theobromine because it varies from one brand of chocolate to another and/or depending on the percentage of cocoa it has. Assuming that there is a correlation, we postulate that the conclusion may be the opposite, that is, that depressed individuals benefit from the intake of products containing theobromine. Since some antidepressant drugs alter the craving for sweet products, it would be interesting to try to correlate the data on theobromine intake with the kind of therapy used in depressed individuals.
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spelling doaj.art-8ee9a7616ffd40878eab121cd9121a8c2023-06-18T11:21:34ZengBMCBMC Psychiatry1471-244X2023-06-012311410.1186/s12888-023-04662-7One-way or two-way sweet link between theobromine and depression?Rafael Franco0Eva Martínez-Pinilla1Molecular Neurobiology laboratory, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de BarcelonaDepartment of Morphology and Cell Biology, Faculty of Medicine, University of OviedoAbstract Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the risk of depression, the diagnosis of which is not simple to make. Also, it is not easy to assess the amount of theobromine because it varies from one brand of chocolate to another and/or depending on the percentage of cocoa it has. Assuming that there is a correlation, we postulate that the conclusion may be the opposite, that is, that depressed individuals benefit from the intake of products containing theobromine. Since some antidepressant drugs alter the craving for sweet products, it would be interesting to try to correlate the data on theobromine intake with the kind of therapy used in depressed individuals.https://doi.org/10.1186/s12888-023-04662-7
spellingShingle Rafael Franco
Eva Martínez-Pinilla
One-way or two-way sweet link between theobromine and depression?
BMC Psychiatry
title One-way or two-way sweet link between theobromine and depression?
title_full One-way or two-way sweet link between theobromine and depression?
title_fullStr One-way or two-way sweet link between theobromine and depression?
title_full_unstemmed One-way or two-way sweet link between theobromine and depression?
title_short One-way or two-way sweet link between theobromine and depression?
title_sort one way or two way sweet link between theobromine and depression
url https://doi.org/10.1186/s12888-023-04662-7
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