A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

Abstract Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is linked to tumor cell heterogeneity remains unclear. We developed a method to measure the stiffness heterogeneity in...

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Bibliographic Details
Main Authors: Connor Stashko, Mary-Kate Hayward, Jason J. Northey, Neil Pearson, Alastair J. Ironside, Johnathon N. Lakins, Roger Oria, Marie-Anne Goyette, Lakyn Mayo, Hege G. Russnes, E. Shelley Hwang, Matthew L. Kutys, Kornelia Polyak, Valerie M. Weaver
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39085-1

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