The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus
Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glyc...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-12-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060518790870 |
| _version_ | 1818575117928628224 |
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| author | Toshihiro Higashikawa Tomohiko Ito Takurou Mizuno Keiichirou Ishigami Masaru Kohori Kunihiro Mae Ryusho Sangen Daisuke Usuda Atsushi Saito Masaharu Iguchi Yuji Kasamaki Akihiro Fukuda Hitoshi Saito Tsugiyasu Kanda Masashi Okuro |
| author_facet | Toshihiro Higashikawa Tomohiko Ito Takurou Mizuno Keiichirou Ishigami Masaru Kohori Kunihiro Mae Ryusho Sangen Daisuke Usuda Atsushi Saito Masaharu Iguchi Yuji Kasamaki Akihiro Fukuda Hitoshi Saito Tsugiyasu Kanda Masashi Okuro |
| author_sort | Toshihiro Higashikawa |
| collection | DOAJ |
| description | Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. Results Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. Conclusion This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration. |
| first_indexed | 2024-12-15T00:36:00Z |
| format | Article |
| id | doaj.art-8ef07f367e33410f85fd1a1d0258dad5 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-15T00:36:00Z |
| publishDate | 2018-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-8ef07f367e33410f85fd1a1d0258dad52022-12-21T22:41:47ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002018-12-014610.1177/0300060518790870The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitusToshihiro HigashikawaTomohiko ItoTakurou MizunoKeiichirou IshigamiMasaru KohoriKunihiro MaeRyusho SangenDaisuke UsudaAtsushi SaitoMasaharu IguchiYuji KasamakiAkihiro FukudaHitoshi SaitoTsugiyasu KandaMasashi OkuroObjective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. Results Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. Conclusion This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration.https://doi.org/10.1177/0300060518790870 |
| spellingShingle | Toshihiro Higashikawa Tomohiko Ito Takurou Mizuno Keiichirou Ishigami Masaru Kohori Kunihiro Mae Ryusho Sangen Daisuke Usuda Atsushi Saito Masaharu Iguchi Yuji Kasamaki Akihiro Fukuda Hitoshi Saito Tsugiyasu Kanda Masashi Okuro The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus Journal of International Medical Research |
| title | The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus |
| title_full | The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus |
| title_fullStr | The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus |
| title_full_unstemmed | The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus |
| title_short | The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus |
| title_sort | effects of 12 month administration of tofogliflozin on electrolytes and dehydration in mainly elderly japanese patients with type 2 diabetes mellitus |
| url | https://doi.org/10.1177/0300060518790870 |
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