ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES
This work represents the synthesis and characterization some new versatile intermediates namely4-amino-1,2,4-triazole-5(4<em>H</em>)-thionederivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
El Oued University
2015-09-01
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| Series: | Journal of Fundamental and Applied Sciences |
| Online Access: | http://jfas.info/index.php/jfas/article/view/41 |
| _version_ | 1811212310081961984 |
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| author | P. S. Manjula B. K. Sarojini C. G. Darshan Raj |
| author_facet | P. S. Manjula B. K. Sarojini C. G. Darshan Raj |
| author_sort | P. S. Manjula |
| collection | DOAJ |
| description | This work represents the synthesis and characterization some new versatile intermediates namely4-amino-1,2,4-triazole-5(4<em>H</em>)-thionederivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four steps. The antibacterial activity of compounds is tested against <em>Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphilococcusaureus</em>. The compounds exhibited species specific activity. Among the tested compounds,<strong>1a</strong> and <strong>1b</strong> exhibited good activity at moderately low concentration (31.25µg/mL)against tested strains of bacteria.DPPH (1,1-diphenyl-2-picryl-hydrazyl), FRAP (ferric reducing antioxidant power) and Lipid peroxidation assays are performed to determine the<em>in vitro</em> antioxidant activities. The compound <strong>1e</strong> exhibited good antioxidant activity among the tested compounds. |
| first_indexed | 2024-04-12T05:27:06Z |
| format | Article |
| id | doaj.art-8ef3385be2ca4039aef2e58dd1b26410 |
| institution | Directory Open Access Journal |
| issn | 1112-9867 |
| language | English |
| last_indexed | 2024-04-12T05:27:06Z |
| publishDate | 2015-09-01 |
| publisher | El Oued University |
| record_format | Article |
| series | Journal of Fundamental and Applied Sciences |
| spelling | doaj.art-8ef3385be2ca4039aef2e58dd1b264102022-12-22T03:46:15ZengEl Oued UniversityJournal of Fundamental and Applied Sciences1112-98672015-09-017339440710.4314/jfas.v7i3.732ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVESP. S. Manjula0B. K. Sarojini1C. G. Darshan Raj2Department of Chemistry, P.A College of Engineering, Nadupadavu, Mangalore – 574153Department of Industrial Chemistry, Mangalore University, Mangalagangothri, Mangalore - 574199,Beaey's Institute of TechnologyThis work represents the synthesis and characterization some new versatile intermediates namely4-amino-1,2,4-triazole-5(4<em>H</em>)-thionederivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four steps. The antibacterial activity of compounds is tested against <em>Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphilococcusaureus</em>. The compounds exhibited species specific activity. Among the tested compounds,<strong>1a</strong> and <strong>1b</strong> exhibited good activity at moderately low concentration (31.25µg/mL)against tested strains of bacteria.DPPH (1,1-diphenyl-2-picryl-hydrazyl), FRAP (ferric reducing antioxidant power) and Lipid peroxidation assays are performed to determine the<em>in vitro</em> antioxidant activities. The compound <strong>1e</strong> exhibited good antioxidant activity among the tested compounds.http://jfas.info/index.php/jfas/article/view/41 |
| spellingShingle | P. S. Manjula B. K. Sarojini C. G. Darshan Raj ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES Journal of Fundamental and Applied Sciences |
| title | ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES |
| title_full | ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES |
| title_fullStr | ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES |
| title_full_unstemmed | ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES |
| title_short | ANTIBACTERIAL AND IN VITRO ANTIOXIDANT ACTIVITIES OF SOME 4-AMINO-1,2,4-TRIAZOLE-5(4H)-THIONE DERIVATIVES |
| title_sort | antibacterial and in vitro antioxidant activities of some 4 amino 1 2 4 triazole 5 4h thione derivatives |
| url | http://jfas.info/index.php/jfas/article/view/41 |
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