Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children
Background: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Methods: Clinical chara...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/9/1940 |
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| author | Angela Guarina Angelica Barone Assunta Tornesello Maddalena Marinoni Giuseppe Lassandro Paola Giordano Milena Motta Marco Spinelli Ilaria Fontanili Fiorina Giona Francesco Menna Elena Chiocca Ilaria Fotzi Angelamaria Petrone Francesco Graziano Paola Saracco Giuseppe Puccio Michele Citrano Giovanna Russo Piero Farruggia |
| author_facet | Angela Guarina Angelica Barone Assunta Tornesello Maddalena Marinoni Giuseppe Lassandro Paola Giordano Milena Motta Marco Spinelli Ilaria Fontanili Fiorina Giona Francesco Menna Elena Chiocca Ilaria Fotzi Angelamaria Petrone Francesco Graziano Paola Saracco Giuseppe Puccio Michele Citrano Giovanna Russo Piero Farruggia |
| author_sort | Angela Guarina |
| collection | DOAJ |
| description | Background: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Methods: Clinical characteristics of both IBD and ITP, onset of disorders, and patient’s response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders. Result: Centers responded to the survey and reported the coexistence of IBD and ITP in 14 children. The first diagnosis was ITP in 57.1% and IBD in 35.7% of patients: it was simultaneous in 7.1%. IBD was classified as ulcerative colitis (57.1%), Crohn disease (35.7%), and unclassified (7.1%). No therapy for IBD other than steroids had any effect on ITP course. Colectomy resulted in recovery from ITP in 1 of the 2 patients surgically treated. ITP was always mild but turned to be chronic in half of patients. Conclusions: In all patients, ITP was mild without any evident impact on IBD severity, but the incidence of chronic ITP seems to be higher than what is usually observed in the pediatric age group. Colectomy had unpredictable effects on ITP. |
| first_indexed | 2024-03-10T11:46:23Z |
| format | Article |
| id | doaj.art-8ef5053ad7d54cfca86aa05288c46257 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:46:23Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8ef5053ad7d54cfca86aa05288c462572023-11-21T18:03:02ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01109194010.3390/jcm10091940Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in ChildrenAngela Guarina0Angelica Barone1Assunta Tornesello2Maddalena Marinoni3Giuseppe Lassandro4Paola Giordano5Milena Motta6Marco Spinelli7Ilaria Fontanili8Fiorina Giona9Francesco Menna10Elena Chiocca11Ilaria Fotzi12Angelamaria Petrone13Francesco Graziano14Paola Saracco15Giuseppe Puccio16Michele Citrano17Giovanna Russo18Piero Farruggia19UOC Oncoematologia Pediatrica—ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, ItalyUO Pediatria e Oncoematologia—AOU, 43126 Parma, ItalyUOC Di Oncoematologia Pediatrica—PO “Vito Fazzi”, 73100 Lecce, ItalySSD Oncoematologia Pediatrica-Ospedale Filippo Del Ponte, Varese ASST Settelaghi, 21100 Varese, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70121 Bari, ItalyUOC Ematologia ed Oncologia Pediatrica—AOU Policlinico “Rodolico-San Marco”, Università di Catania, 95131 Catania, ItalyFondazione MBBM/AO San Gerardo Clinica Pediatrica Universitaria, 20900 Monza, ItalyUO Pediatria e Oncoematologia—AOU, 43126 Parma, ItalyPoliclinico Umberto I, Università La Sapienza, 00185 Roma, ItalyDipartimento di Oncoematologia–AORN Santobono-Pausilipon, 80122 Napoli, ItalyOncologia, Ematologia e TCSE—Centro di Eccellenza di Oncologia ed Ematologia—AOU A. Meyer, 50139 Firenze, ItalyOncologia, Ematologia e TCSE—Centro di Eccellenza di Oncologia ed Ematologia—AOU A. Meyer, 50139 Firenze, ItalyUOM Pediatria Ospedale S. Chiara, 38122 Trento, ItalyUO di Pediatria–Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, 90146 Palermo, ItalyDipartimento di Scienze Pediatriche e dell’Adolescenza, SC Pediatria Specialistica Universitaria, AOU Città della Salute e della Scienza, Presidio Ospedale Infantile Regina Margherita, 10126 Torino, ItalyUOC Oncoematologia Pediatrica—ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, ItalyUO di Pediatria–Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, 90146 Palermo, ItalyUOC Ematologia ed Oncologia Pediatrica—AOU Policlinico “Rodolico-San Marco”, Università di Catania, 95131 Catania, ItalyUOC Oncoematologia Pediatrica—ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, ItalyBackground: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Methods: Clinical characteristics of both IBD and ITP, onset of disorders, and patient’s response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders. Result: Centers responded to the survey and reported the coexistence of IBD and ITP in 14 children. The first diagnosis was ITP in 57.1% and IBD in 35.7% of patients: it was simultaneous in 7.1%. IBD was classified as ulcerative colitis (57.1%), Crohn disease (35.7%), and unclassified (7.1%). No therapy for IBD other than steroids had any effect on ITP course. Colectomy resulted in recovery from ITP in 1 of the 2 patients surgically treated. ITP was always mild but turned to be chronic in half of patients. Conclusions: In all patients, ITP was mild without any evident impact on IBD severity, but the incidence of chronic ITP seems to be higher than what is usually observed in the pediatric age group. Colectomy had unpredictable effects on ITP.https://www.mdpi.com/2077-0383/10/9/1940bowelchildrenimmunethrombocytopeniapediatric |
| spellingShingle | Angela Guarina Angelica Barone Assunta Tornesello Maddalena Marinoni Giuseppe Lassandro Paola Giordano Milena Motta Marco Spinelli Ilaria Fontanili Fiorina Giona Francesco Menna Elena Chiocca Ilaria Fotzi Angelamaria Petrone Francesco Graziano Paola Saracco Giuseppe Puccio Michele Citrano Giovanna Russo Piero Farruggia Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children Journal of Clinical Medicine bowel children immune thrombocytopenia pediatric |
| title | Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children |
| title_full | Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children |
| title_fullStr | Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children |
| title_full_unstemmed | Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children |
| title_short | Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children |
| title_sort | association of immune thrombocytopenia and inflammatory bowel disease in children |
| topic | bowel children immune thrombocytopenia pediatric |
| url | https://www.mdpi.com/2077-0383/10/9/1940 |
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