Leishmania promastigotes: building a safe niche within macrophages
Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accum...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00121/full |
| _version_ | 1819228588636897280 |
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| author | Neda eMoradin Albert eDescoteaux |
| author_facet | Neda eMoradin Albert eDescoteaux |
| author_sort | Neda eMoradin |
| collection | DOAJ |
| description | Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole. |
| first_indexed | 2024-12-23T10:59:40Z |
| format | Article |
| id | doaj.art-8ef5fb14e98e4cb0a4d933a52f8dc738 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-23T10:59:40Z |
| publishDate | 2012-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-8ef5fb14e98e4cb0a4d933a52f8dc7382022-12-21T17:49:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882012-09-01210.3389/fcimb.2012.0012132475Leishmania promastigotes: building a safe niche within macrophagesNeda eMoradin0Albert eDescoteaux1INRS- Institut Armand-FrappierINRS- Institut Armand-FrappierUpon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00121/fullLeishmaniaVirulencelipophosphoglycanmacrophagephagosome |
| spellingShingle | Neda eMoradin Albert eDescoteaux Leishmania promastigotes: building a safe niche within macrophages Frontiers in Cellular and Infection Microbiology Leishmania Virulence lipophosphoglycan macrophage phagosome |
| title | Leishmania promastigotes: building a safe niche within macrophages |
| title_full | Leishmania promastigotes: building a safe niche within macrophages |
| title_fullStr | Leishmania promastigotes: building a safe niche within macrophages |
| title_full_unstemmed | Leishmania promastigotes: building a safe niche within macrophages |
| title_short | Leishmania promastigotes: building a safe niche within macrophages |
| title_sort | leishmania promastigotes building a safe niche within macrophages |
| topic | Leishmania Virulence lipophosphoglycan macrophage phagosome |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00121/full |
| work_keys_str_mv | AT nedaemoradin leishmaniapromastigotesbuildingasafenichewithinmacrophages AT albertedescoteaux leishmaniapromastigotesbuildingasafenichewithinmacrophages |