Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease
Abstract The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-023-00535-8 |
| _version_ | 1827615240175484928 |
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| author | Amica C. Müller-Nedebock Marieke C. J. Dekker Matthew J. Farrer Nobutaka Hattori Shen-Yang Lim George D. Mellick Irena Rektorová Mohamed Salama Artur F. S. Schuh A. Jon Stoessl Carolyn M. Sue Ai Huey Tan Rene L. Vidal Christine Klein Soraya Bardien |
| author_facet | Amica C. Müller-Nedebock Marieke C. J. Dekker Matthew J. Farrer Nobutaka Hattori Shen-Yang Lim George D. Mellick Irena Rektorová Mohamed Salama Artur F. S. Schuh A. Jon Stoessl Carolyn M. Sue Ai Huey Tan Rene L. Vidal Christine Klein Soraya Bardien |
| author_sort | Amica C. Müller-Nedebock |
| collection | DOAJ |
| description | Abstract The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen “PD experts” from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen. |
| first_indexed | 2024-03-09T09:07:14Z |
| format | Article |
| id | doaj.art-8ef87602d608417f925cb5814711f73b |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T09:07:14Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-8ef87602d608417f925cb5814711f73b2023-12-02T09:50:28ZengNature Portfolionpj Parkinson's Disease2373-80572023-07-019111110.1038/s41531-023-00535-8Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s diseaseAmica C. Müller-Nedebock0Marieke C. J. Dekker1Matthew J. Farrer2Nobutaka Hattori3Shen-Yang Lim4George D. Mellick5Irena Rektorová6Mohamed Salama7Artur F. S. Schuh8A. Jon Stoessl9Carolyn M. Sue10Ai Huey Tan11Rene L. Vidal12Christine Klein13Soraya Bardien14Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch UniversityDepartment of Internal Medicine, Kilimanjaro Christian Medical CentreNorman Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of FloridaResearch Institute of Disease of Old Age, Graduate School of Medicine, Juntendo UniversityDivision of Neurology, Department of Medicine, Faculty of Medicine, University of MalayaGriffith Institute of Drug Discovery (GRIDD), Griffith UniversityFirst Department of Neurology and International Clinical Research Center, St. Anne’s University Hospital and Faculty of Medicine, Masaryk UniversityInstitute of Global Health and Human Ecology (I-GHHE), The American University in Cairo (AUC)Departamento de Farmacologia, Universidade Federal do Rio Grande do SulPacific Parkinson’s Research Centre, Department of Medicine (Division of Neurology), Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaNeuroscience Research Australia; Faculty of Medicine, University of New South Wales; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst; Department of Neurology, Prince of Wales Hospital, South Eastern Sydney Local Health DistrictDivision of Neurology, Department of Medicine, Faculty of Medicine, University of MalayaInstituto de Neurociencia Biomédica (BNI), Facultad de Medicina, Universidad de ChileInstitute of Neurogenetics, University of Lübeck and University Hospital Schleswig-HolsteinDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch UniversityAbstract The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen “PD experts” from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.https://doi.org/10.1038/s41531-023-00535-8 |
| spellingShingle | Amica C. Müller-Nedebock Marieke C. J. Dekker Matthew J. Farrer Nobutaka Hattori Shen-Yang Lim George D. Mellick Irena Rektorová Mohamed Salama Artur F. S. Schuh A. Jon Stoessl Carolyn M. Sue Ai Huey Tan Rene L. Vidal Christine Klein Soraya Bardien Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease npj Parkinson's Disease |
| title | Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease |
| title_full | Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease |
| title_fullStr | Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease |
| title_full_unstemmed | Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease |
| title_short | Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease |
| title_sort | different pieces of the same puzzle a multifaceted perspective on the complex biological basis of parkinson s disease |
| url | https://doi.org/10.1038/s41531-023-00535-8 |
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