Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis
Background: The intra- and postoperative effects of dexmedetomidine are not completely consistent and midazolam/fentanyl is most widely used in peripheral surgeries. The objectives of the study were to evaluate the sedative, analgesic, hemodynamic, anti-inflammatory, and antioxidant effects of dexme...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-04-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325820916342 |
| _version_ | 1819278618729119744 |
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| author | Jing Peng Fujuan He Chenguang Qin Yuanyuan Que Rui Fan Bin Qin |
| author_facet | Jing Peng Fujuan He Chenguang Qin Yuanyuan Que Rui Fan Bin Qin |
| author_sort | Jing Peng |
| collection | DOAJ |
| description | Background: The intra- and postoperative effects of dexmedetomidine are not completely consistent and midazolam/fentanyl is most widely used in peripheral surgeries. The objectives of the study were to evaluate the sedative, analgesic, hemodynamic, anti-inflammatory, and antioxidant effects of dexmedetomidine against midazolam in patients undergoing peripheral surgeries with mild traumatic brain injuries. Methods: Medical records of patients who underwent peripheral surgeries with mild traumatic brain injury were included in the analysis. Patients received intraoperative midazolam (MDZ cohort, n = 225) or dexmedetomidine (DEX cohort, n = 231). Pre-, intra-, and postoperative characteristics of patients were collected and analyzed. Results: After administration of anesthesia, up to 40 minutes, patients of the MDZ group had lower modified observer’s assessment of alertness/sedation score than those of the DEX group ( P = .041), but after 40 minutes, patients of the MDZ group had a higher score than those of the DEX group throughout surgeries ( P = 0.048). The DEX group has less requirements of postoperative morphine/equivalent doses than the MDZ group (4 ± 1 vs 5 ± 1, P < .0001, q = 18.451). Conclusions: Intraoperative DEX offers better sedation, postoperative analgesia, and clinical recovery for peripheral surgeries and suppresses inflammatory response. Level of Evidence: III. |
| first_indexed | 2024-12-24T00:14:53Z |
| format | Article |
| id | doaj.art-8ef93e1fa8bc444ea0f26dacd0130104 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-24T00:14:53Z |
| publishDate | 2020-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-8ef93e1fa8bc444ea0f26dacd01301042022-12-21T17:24:46ZengSAGE PublishingDose-Response1559-32582020-04-011810.1177/1559325820916342Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort AnalysisJing Peng0Fujuan He1Chenguang Qin2Yuanyuan Que3Rui Fan4Bin Qin5 Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of Oral and Maxillofacial Surgery, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaBackground: The intra- and postoperative effects of dexmedetomidine are not completely consistent and midazolam/fentanyl is most widely used in peripheral surgeries. The objectives of the study were to evaluate the sedative, analgesic, hemodynamic, anti-inflammatory, and antioxidant effects of dexmedetomidine against midazolam in patients undergoing peripheral surgeries with mild traumatic brain injuries. Methods: Medical records of patients who underwent peripheral surgeries with mild traumatic brain injury were included in the analysis. Patients received intraoperative midazolam (MDZ cohort, n = 225) or dexmedetomidine (DEX cohort, n = 231). Pre-, intra-, and postoperative characteristics of patients were collected and analyzed. Results: After administration of anesthesia, up to 40 minutes, patients of the MDZ group had lower modified observer’s assessment of alertness/sedation score than those of the DEX group ( P = .041), but after 40 minutes, patients of the MDZ group had a higher score than those of the DEX group throughout surgeries ( P = 0.048). The DEX group has less requirements of postoperative morphine/equivalent doses than the MDZ group (4 ± 1 vs 5 ± 1, P < .0001, q = 18.451). Conclusions: Intraoperative DEX offers better sedation, postoperative analgesia, and clinical recovery for peripheral surgeries and suppresses inflammatory response. Level of Evidence: III.https://doi.org/10.1177/1559325820916342 |
| spellingShingle | Jing Peng Fujuan He Chenguang Qin Yuanyuan Que Rui Fan Bin Qin Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis Dose-Response |
| title | Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis |
| title_full | Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis |
| title_fullStr | Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis |
| title_full_unstemmed | Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis |
| title_short | Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis |
| title_sort | intraoperative dexmedetomidine versus midazolam in patients undergoing peripheral surgery with mild traumatic brain injuries a retrospective cohort analysis |
| url | https://doi.org/10.1177/1559325820916342 |
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