Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder
Intracortical myelin is involved in speeding and synchronizing neural activity of the cerebral cortex and has been found to be disrupted in various psychiatric disorders. However, its role in obsessive–compulsive disorder (OCD) has remained unknown. In this study, we investigated the alterations in...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222001875 |
| _version_ | 1818477700143120384 |
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| author | Qihui Niu Jianyu Li Lei Yang Zitong Huang Mingmin Niu Xueqin Song Yuanchao Zhang Youhui Li |
| author_facet | Qihui Niu Jianyu Li Lei Yang Zitong Huang Mingmin Niu Xueqin Song Yuanchao Zhang Youhui Li |
| author_sort | Qihui Niu |
| collection | DOAJ |
| description | Intracortical myelin is involved in speeding and synchronizing neural activity of the cerebral cortex and has been found to be disrupted in various psychiatric disorders. However, its role in obsessive–compulsive disorder (OCD) has remained unknown. In this study, we investigated the alterations in intracortical myelin and their association with white matter (WM) microstructural abnormalities in OCD. T1-weighted and diffusion-weighted brain images were obtained for 51 medication-naïve patients with OCD and 26 healthy controls (HCs). The grey/white matter contrast (GWC) was calculated from T1-weighted signal intensities to characterize the intracortical myelin profile in OCD. Diffusion parameters, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were extracted from diffusion-weighted images to examine the WM microstructure in OCD. Compared with HCs, patients with OCD showed increased GWC in the bilateral orbitofrontal, cuneus, lingual and fusiform gyrus, left anterior cingulate, left superior parietal, right inferior parietal, and right middle frontal cortices, suggesting reduced intracortical myelin. Patients with OCD also showed decreased FA in several WM regions, with a topology corresponding to the GWC alterations. In both groups, the mean GWC of the significant clusters in between-group GWC analysis was correlated negatively with the mean FA of the significant clusters in between-group FA analysis. In patients with OCD, the FA of a cluster in the right cerebellum correlated negatively with the Yale-Brown obsessive–compulsive scale scores. Our results suggest that abnormal intracortical and WM myelination could be the microstructural basis for the brain connectivity alterations and disrupted inhibitory control in OCD. |
| first_indexed | 2024-12-10T09:40:26Z |
| format | Article |
| id | doaj.art-8ef9b505c74546faa3e14e140e08590d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-10T09:40:26Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-8ef9b505c74546faa3e14e140e08590d2022-12-22T01:54:01ZengElsevierNeuroImage: Clinical2213-15822022-01-0135103122Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorderQihui Niu0Jianyu Li1Lei Yang2Zitong Huang3Mingmin Niu4Xueqin Song5Yuanchao Zhang6Youhui Li7Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Organization, Zhengzhou Railway Vocational and Technical College, Zhengzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Corresponding authors at: School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (Yuanchao Zhang), Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou 450052, China (Youhui Li).Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Corresponding authors at: School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (Yuanchao Zhang), Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou 450052, China (Youhui Li).Intracortical myelin is involved in speeding and synchronizing neural activity of the cerebral cortex and has been found to be disrupted in various psychiatric disorders. However, its role in obsessive–compulsive disorder (OCD) has remained unknown. In this study, we investigated the alterations in intracortical myelin and their association with white matter (WM) microstructural abnormalities in OCD. T1-weighted and diffusion-weighted brain images were obtained for 51 medication-naïve patients with OCD and 26 healthy controls (HCs). The grey/white matter contrast (GWC) was calculated from T1-weighted signal intensities to characterize the intracortical myelin profile in OCD. Diffusion parameters, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were extracted from diffusion-weighted images to examine the WM microstructure in OCD. Compared with HCs, patients with OCD showed increased GWC in the bilateral orbitofrontal, cuneus, lingual and fusiform gyrus, left anterior cingulate, left superior parietal, right inferior parietal, and right middle frontal cortices, suggesting reduced intracortical myelin. Patients with OCD also showed decreased FA in several WM regions, with a topology corresponding to the GWC alterations. In both groups, the mean GWC of the significant clusters in between-group GWC analysis was correlated negatively with the mean FA of the significant clusters in between-group FA analysis. In patients with OCD, the FA of a cluster in the right cerebellum correlated negatively with the Yale-Brown obsessive–compulsive scale scores. Our results suggest that abnormal intracortical and WM myelination could be the microstructural basis for the brain connectivity alterations and disrupted inhibitory control in OCD.http://www.sciencedirect.com/science/article/pii/S2213158222001875Obsessive-compulsive disorderGray/white matter contrastWhite matter microstructure |
| spellingShingle | Qihui Niu Jianyu Li Lei Yang Zitong Huang Mingmin Niu Xueqin Song Yuanchao Zhang Youhui Li Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder NeuroImage: Clinical Obsessive-compulsive disorder Gray/white matter contrast White matter microstructure |
| title | Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder |
| title_full | Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder |
| title_fullStr | Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder |
| title_full_unstemmed | Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder |
| title_short | Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder |
| title_sort | association between gray white matter contrast and white matter microstructural alterations in medication naive obsessive compulsive disorder |
| topic | Obsessive-compulsive disorder Gray/white matter contrast White matter microstructure |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222001875 |
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