Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks

Abstract Background CircRNA CNST (circ-CNST) is a newly identified biomarker for prognosis of osteosarcoma (OS). However, its role in OS progression remains to be well documented. Methods Expression of circ-CNST, microRNA (miR)-578, lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1...

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Bibliographic Details
Main Authors: Rui Hu, Shan Chen, Jianxin Yan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Circ-CNST
miR-578
Osteosarcoma
Glycolysis
LDHA
PDK1
Online Access:https://doi.org/10.1186/s13018-021-02427-0

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