Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes
Abstract Objective To evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging. Methods We retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10 ± 9.9 years) with confi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1752 |
| _version_ | 1797375192769495040 |
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| author | Saeid Esmaeilian Arash Teimouri Sedighe Hooshmandi Mohammad Hossein Nikoo Seyed Taghi Heydari Elham Mohajeri Sina Bazmi Reza Tabrizi Meisam Hoseinyazdi |
| author_facet | Saeid Esmaeilian Arash Teimouri Sedighe Hooshmandi Mohammad Hossein Nikoo Seyed Taghi Heydari Elham Mohajeri Sina Bazmi Reza Tabrizi Meisam Hoseinyazdi |
| author_sort | Saeid Esmaeilian |
| collection | DOAJ |
| description | Abstract Objective To evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging. Methods We retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10 ± 9.9 years) with confirmed methanol poisoning who were admitted to two hospitals in Iran during the COVID‐19 pandemic. We analyzed their demographic, clinical, laboratory, and brain imaging data. Results The main brain computed tomography (CT) scan findings were hypodensity in the putamen (11.1%), cerebellar nuclei (8.2%), diffuse cerebral edema (7.5%), and intracranial hemorrhage (ICH; 1.6%). These findings were associated with blood pH, Glasgow Coma Scale (GCS), renal failure, bicarbonate, oxygen, carbon dioxide, potassium, and glucose levels (p < 0.05). Poor prognosis was related to blindness, opium addiction, chronic alcohol use, hyperglycemia, and abnormal CT scans (p < 0.001 for all). The most predictive brain imaging findings for poor prognosis were hypodensity in the cerebellar nuclei, diffuse cerebral edema, and ICH. Conclusion Brain imaging can provide valuable information for the diagnosis and management of methanol poisoning patients. We suggest that patients with severe acidosis, low GCS, low pH, low oxygen saturation, and high glucose levels should undergo brain CT scan as a priority. |
| first_indexed | 2024-03-08T19:18:42Z |
| format | Article |
| id | doaj.art-8efdeb49df804af1ab588e743fec5a59 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T19:18:42Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-8efdeb49df804af1ab588e743fec5a592023-12-27T00:48:32ZengWileyHealth Science Reports2398-88352023-12-01612n/an/a10.1002/hsr2.1752Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomesSaeid Esmaeilian0Arash Teimouri1Sedighe Hooshmandi2Mohammad Hossein Nikoo3Seyed Taghi Heydari4Elham Mohajeri5Sina Bazmi6Reza Tabrizi7Meisam Hoseinyazdi8Health Policy Research Center, Institute of Health Shiraz University of Medical Sciences Shiraz IranMedical Imaging Research Center Shiraz University of Medical Sciences Shiraz IranMedical Imaging Research Center Shiraz University of Medical Sciences Shiraz IranNoncommunicable Diseases Research Centre Shiraz University of Medical Sciences Shiraz IranHealth Policy Research Center, Institute of Health Shiraz University of Medical Sciences Shiraz IranHealth Policy Research Center, Institute of Health Shiraz University of Medical Sciences Shiraz IranStudent Research Committee Fasa University of Medical Sciences Fasa IranClinical Research Development Unit, Valiasr Hospital Fasa University of Medical Sciences Fasa IranRussell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Hospital Baltimore Maryland USAAbstract Objective To evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging. Methods We retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10 ± 9.9 years) with confirmed methanol poisoning who were admitted to two hospitals in Iran during the COVID‐19 pandemic. We analyzed their demographic, clinical, laboratory, and brain imaging data. Results The main brain computed tomography (CT) scan findings were hypodensity in the putamen (11.1%), cerebellar nuclei (8.2%), diffuse cerebral edema (7.5%), and intracranial hemorrhage (ICH; 1.6%). These findings were associated with blood pH, Glasgow Coma Scale (GCS), renal failure, bicarbonate, oxygen, carbon dioxide, potassium, and glucose levels (p < 0.05). Poor prognosis was related to blindness, opium addiction, chronic alcohol use, hyperglycemia, and abnormal CT scans (p < 0.001 for all). The most predictive brain imaging findings for poor prognosis were hypodensity in the cerebellar nuclei, diffuse cerebral edema, and ICH. Conclusion Brain imaging can provide valuable information for the diagnosis and management of methanol poisoning patients. We suggest that patients with severe acidosis, low GCS, low pH, low oxygen saturation, and high glucose levels should undergo brain CT scan as a priority.https://doi.org/10.1002/hsr2.1752brain CTCOVID‐19 pandemicmethanol poisoningprognosis |
| spellingShingle | Saeid Esmaeilian Arash Teimouri Sedighe Hooshmandi Mohammad Hossein Nikoo Seyed Taghi Heydari Elham Mohajeri Sina Bazmi Reza Tabrizi Meisam Hoseinyazdi Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes Health Science Reports brain CT COVID‐19 pandemic methanol poisoning prognosis |
| title | Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes |
| title_full | Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes |
| title_fullStr | Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes |
| title_full_unstemmed | Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes |
| title_short | Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes |
| title_sort | methanol poisoning during the covid 19 pandemic in iran a retrospective cross sectional study of clinical laboratory and brain imaging characteristics and outcomes |
| topic | brain CT COVID‐19 pandemic methanol poisoning prognosis |
| url | https://doi.org/10.1002/hsr2.1752 |
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