Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with apolipoprotein E (<i>APOE</i>) and neurodegeneration. The E4 allele of <i>APOE</i> (E4) is the strongest genetic risk factor for the development of late onset Alzheimer&#8217;s disease (AD)...

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Bibliographic Details
Main Authors: Brandon C. Farmer, Jude Kluemper, Lance A. Johnson
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
APOE
astrocytes
lipid droplets
lipid metabolism
AD
PLIN-2
fatty acid oxidation
Online Access:https://www.mdpi.com/2073-4409/8/2/182

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