Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage
Abstract The International Agency for Research on Cancer has classified semimetal arsenic as a human carcinogen. Arsenic poisoning can severely impact human health. Arsenic can be classified into inorganic and organic arsenic, with arsenolipids (AsLs) belonging to the category of organic arsenic. Th...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | eFood |
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| Online Access: | https://doi.org/10.1002/efd2.99 |
| _version_ | 1797743796172095488 |
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| author | Jiajia Chen Yingxiong Zhong Xiaofei Liu Zhuo Wang Jianping Chen Bingbing Song Rui Li Xuejing Jia Saiyi Zhong Xinhuang Kang |
| author_facet | Jiajia Chen Yingxiong Zhong Xiaofei Liu Zhuo Wang Jianping Chen Bingbing Song Rui Li Xuejing Jia Saiyi Zhong Xinhuang Kang |
| author_sort | Jiajia Chen |
| collection | DOAJ |
| description | Abstract The International Agency for Research on Cancer has classified semimetal arsenic as a human carcinogen. Arsenic poisoning can severely impact human health. Arsenic can be classified into inorganic and organic arsenic, with arsenolipids (AsLs) belonging to the category of organic arsenic. The primary species of AsLs include arsenic‐containing hydrocarbons (AsHCs), fatty acids, and phospholipids. AsLs are highly abundant in marine organisms and diet may be the primary source of exposure to AsLs. Although increasing evidence shows that AsLs are cytotoxic to humans, the specific toxicity and its mechanism remain unclear. This study aimed to evaluate the hepatotoxicity and possible mechanisms of the toxic effects of AsLs in mice. Three AsLs (AsHC 332, AsHC 346, and AsHC 374) were administered via gavage at a dose of 3 mg/kg for 4 weeks. The results showed that short‐term exposure did not affect the normal growth and development of mice. However, it caused liver damage in mice, mainly by disrupting the metabolism of selenium, copper, zinc, and other elements related to the synthesis of antioxidant enzymes, thereby reducing the activity of antioxidant enzymes and the expression of related genes. The liver damage effect of AsHC 332 was the strongest among the three AsLs. |
| first_indexed | 2024-03-12T15:00:36Z |
| format | Article |
| id | doaj.art-8efe5ca4c32c4663b063ec632383bba0 |
| institution | Directory Open Access Journal |
| issn | 2666-3066 |
| language | English |
| last_indexed | 2024-03-12T15:00:36Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | eFood |
| spelling | doaj.art-8efe5ca4c32c4663b063ec632383bba02023-08-14T08:22:27ZengWileyeFood2666-30662023-08-0144n/an/a10.1002/efd2.99Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damageJiajia Chen0Yingxiong Zhong1Xiaofei Liu2Zhuo Wang3Jianping Chen4Bingbing Song5Rui Li6Xuejing Jia7Saiyi Zhong8Xinhuang Kang9Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology Guangdong Ocean University Zhanjiang ChinaCollege of Chemistry and Environment Guangdong Ocean University Zhanjiang ChinaAbstract The International Agency for Research on Cancer has classified semimetal arsenic as a human carcinogen. Arsenic poisoning can severely impact human health. Arsenic can be classified into inorganic and organic arsenic, with arsenolipids (AsLs) belonging to the category of organic arsenic. The primary species of AsLs include arsenic‐containing hydrocarbons (AsHCs), fatty acids, and phospholipids. AsLs are highly abundant in marine organisms and diet may be the primary source of exposure to AsLs. Although increasing evidence shows that AsLs are cytotoxic to humans, the specific toxicity and its mechanism remain unclear. This study aimed to evaluate the hepatotoxicity and possible mechanisms of the toxic effects of AsLs in mice. Three AsLs (AsHC 332, AsHC 346, and AsHC 374) were administered via gavage at a dose of 3 mg/kg for 4 weeks. The results showed that short‐term exposure did not affect the normal growth and development of mice. However, it caused liver damage in mice, mainly by disrupting the metabolism of selenium, copper, zinc, and other elements related to the synthesis of antioxidant enzymes, thereby reducing the activity of antioxidant enzymes and the expression of related genes. The liver damage effect of AsHC 332 was the strongest among the three AsLs.https://doi.org/10.1002/efd2.99arsenolipidselementliver damageoxidativeqPCR |
| spellingShingle | Jiajia Chen Yingxiong Zhong Xiaofei Liu Zhuo Wang Jianping Chen Bingbing Song Rui Li Xuejing Jia Saiyi Zhong Xinhuang Kang Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage eFood arsenolipids element liver damage oxidative qPCR |
| title | Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| title_full | Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| title_fullStr | Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| title_full_unstemmed | Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| title_short | Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| title_sort | evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage |
| topic | arsenolipids element liver damage oxidative qPCR |
| url | https://doi.org/10.1002/efd2.99 |
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