| Summary: | Four samples of fir honeydew honey from Podkarpackie labeled with a Protected Designation of Origin symbol were tested in terms of their physicochemical parameters, antioxidant, and antibacterial effects, as well as their anti-migration properties against a breast cancer cell line (MCF-7) and fibroblasts. The results confirmed the high quality of tested samples regarding the obligatory parameters, as well as the additional indicators used (antioxidant and enzymatic activity), compared to representative rapeseed honey. Among the tested bacterial strains, the greatest effectiveness was demonstrated against <i>Klebsiella pneumoniae</i> and <i>Streptococcus</i> spp. Moreover, the results obtained in the urease inhibition in vitro test suggested the potential use of honeydew honey in the treatment of urease-positive bacterial infections. For the first time, using a scratch test it was found that the Podkarpackie honeydew honey efficiently affected the migration of cancer breast cells, whereas it only slightly inhibited the movement of normal fibroblasts. It can be suggested that the quality of honey guaranteed by the Protected Designation of Origin label could be the key factor of honeydew honey’s bioactivity and its potential medicinal use.
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