Magnesium and mood disorders: systematic review and meta-analysis
BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2018-07-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472418000224/type/journal_article |
| _version_ | 1811157104295149568 |
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| author | Danny Phelan Patricio Molero Miguel A. Martínez-González Marc Molendijk |
| author_facet | Danny Phelan Patricio Molero Miguel A. Martínez-González Marc Molendijk |
| author_sort | Danny Phelan |
| collection | DOAJ |
| description | BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.MethodSystematic review and meta-analyses.ResultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = −1.60) but not in placebo-controlled trials (g = −0.21).ConclusionOur results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone. |
| first_indexed | 2024-04-10T05:00:27Z |
| format | Article |
| id | doaj.art-8f01f49bca264ddfa8c03752eabd0f21 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:00:27Z |
| publishDate | 2018-07-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-8f01f49bca264ddfa8c03752eabd0f212023-03-09T12:28:47ZengCambridge University PressBJPsych Open2056-47242018-07-01416717910.1192/bjo.2018.22Magnesium and mood disorders: systematic review and meta-analysisDanny Phelan0Patricio Molero1Miguel A. Martínez-González2Marc Molendijk3Institute of Psychology, Clinical Psychology Unit, Leiden University, Leiden, The NetherlandsDepartment of Psychiatry and Medical Psychology, University Hospital, School of Medicine, University of Navarra, Pamplona, Navarra, SpainDepartment of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Navarra, Spain, CIBER-OBN, Instituto de Salud Carlos III, Madrid, Spain, and Department of Nutrition, Harvard TH Chan School of Public Health, Boston, USAInstitute of Psychology, Clinical Psychology Unit, Leiden University, Leiden, The Netherlands, and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.BackgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.MethodSystematic review and meta-analyses.ResultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = −1.60) but not in placebo-controlled trials (g = −0.21).ConclusionOur results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone.https://www.cambridge.org/core/product/identifier/S2056472418000224/type/journal_articleMagnesiumdepressionbipolar disordermeta-analysissystematic review |
| spellingShingle | Danny Phelan Patricio Molero Miguel A. Martínez-González Marc Molendijk Magnesium and mood disorders: systematic review and meta-analysis BJPsych Open Magnesium depression bipolar disorder meta-analysis systematic review |
| title | Magnesium and mood disorders: systematic review and meta-analysis |
| title_full | Magnesium and mood disorders: systematic review and meta-analysis |
| title_fullStr | Magnesium and mood disorders: systematic review and meta-analysis |
| title_full_unstemmed | Magnesium and mood disorders: systematic review and meta-analysis |
| title_short | Magnesium and mood disorders: systematic review and meta-analysis |
| title_sort | magnesium and mood disorders systematic review and meta analysis |
| topic | Magnesium depression bipolar disorder meta-analysis systematic review |
| url | https://www.cambridge.org/core/product/identifier/S2056472418000224/type/journal_article |
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