ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses
<p>Abstract</p> <p>Objective</p> <p>The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/10/1/56 |
| _version_ | 1818474226778112000 |
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| author | Degiannis Dimitrios Kalogiani Antonia Vasilopoulos Georgios Karakosta Agathi Marvaki Apostolia Kolovou Genovefa Kolovou Vana Marvaki Christina Demopoulos Constantinos A |
| author_facet | Degiannis Dimitrios Kalogiani Antonia Vasilopoulos Georgios Karakosta Agathi Marvaki Apostolia Kolovou Genovefa Kolovou Vana Marvaki Christina Demopoulos Constantinos A |
| author_sort | Degiannis Dimitrios |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses.</p> <p>Methods</p> <p>The study population consisted of 308 unrelated nurses who were genotyped and the ABCA1 polymorphisms were detected. Additionally, lipid profile [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] was evaluated.</p> <p>Results</p> <p>There was no difference in the genotypic and allelic frequencies of the R219K polymorphism according to lipid profile. The R1587K genotypes differed significantly according to TC, LDL-C and TGs concentration (p = 0.023, p = 0.014 and p = 0.047, respectively). Particularly, significant difference in TC, LDL-C and TGs concentration was detected between RK and RR genotypes (p = 0.006, p = 0.004, p = 0.014, respectively). Women with RK genotype compared to RR genotype had higher concentration of TGs (134.25 mg/dl vs 108.89 mg/dl, p = 0.014, respectively), total cholesterol (207.41 mg/dl vs 187.69 mg/dl, p = 0.006, respectively), and LDL-C (110.6 mg/dl vs 96.9 mg/dl, p = 0.004, respectively).</p> <p>Conclusions</p> <p>These findings suggest that the R1587K polymorphism of ABCA1 gene was associated with lipid profile of Greek nurses. Women with RK genotype had higher TGs, total and LDL-C concentration compared to RR genotype. These observations may be significant in assessing the risk of CAD since a 1% change in LDL-C is associated with a 1% change of cardiovascular events. Also, TGs concentration were documented to play a significant role in women. However, this needs to be confirmed by larger studies.</p> |
| first_indexed | 2024-04-14T04:34:06Z |
| format | Article |
| id | doaj.art-8f02fec2f0384507ba1c8b9ed0fd98b5 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T04:34:06Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-8f02fec2f0384507ba1c8b9ed0fd98b52022-12-22T02:11:57ZengBMCLipids in Health and Disease1476-511X2011-04-011015610.1186/1476-511X-10-56ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nursesDegiannis DimitriosKalogiani AntoniaVasilopoulos GeorgiosKarakosta AgathiMarvaki ApostoliaKolovou GenovefaKolovou VanaMarvaki ChristinaDemopoulos Constantinos A<p>Abstract</p> <p>Objective</p> <p>The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses.</p> <p>Methods</p> <p>The study population consisted of 308 unrelated nurses who were genotyped and the ABCA1 polymorphisms were detected. Additionally, lipid profile [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] was evaluated.</p> <p>Results</p> <p>There was no difference in the genotypic and allelic frequencies of the R219K polymorphism according to lipid profile. The R1587K genotypes differed significantly according to TC, LDL-C and TGs concentration (p = 0.023, p = 0.014 and p = 0.047, respectively). Particularly, significant difference in TC, LDL-C and TGs concentration was detected between RK and RR genotypes (p = 0.006, p = 0.004, p = 0.014, respectively). Women with RK genotype compared to RR genotype had higher concentration of TGs (134.25 mg/dl vs 108.89 mg/dl, p = 0.014, respectively), total cholesterol (207.41 mg/dl vs 187.69 mg/dl, p = 0.006, respectively), and LDL-C (110.6 mg/dl vs 96.9 mg/dl, p = 0.004, respectively).</p> <p>Conclusions</p> <p>These findings suggest that the R1587K polymorphism of ABCA1 gene was associated with lipid profile of Greek nurses. Women with RK genotype had higher TGs, total and LDL-C concentration compared to RR genotype. These observations may be significant in assessing the risk of CAD since a 1% change in LDL-C is associated with a 1% change of cardiovascular events. Also, TGs concentration were documented to play a significant role in women. However, this needs to be confirmed by larger studies.</p>http://www.lipidworld.com/content/10/1/56 |
| spellingShingle | Degiannis Dimitrios Kalogiani Antonia Vasilopoulos Georgios Karakosta Agathi Marvaki Apostolia Kolovou Genovefa Kolovou Vana Marvaki Christina Demopoulos Constantinos A ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses Lipids in Health and Disease |
| title | ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses |
| title_full | ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses |
| title_fullStr | ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses |
| title_full_unstemmed | ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses |
| title_short | ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses |
| title_sort | atp binding cassette transporter a1 gene polymorphisms and serum lipid levels in young greek nurses |
| url | http://www.lipidworld.com/content/10/1/56 |
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