Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging
Abstract Objectives To compare the white matter (WM) asymmetry in left and right medial temporal lobe epilepsy (mTLE) with and without hippocampal sclerosis (HS+, HS–) and assess the correlation of preoperative asymmetry and the dynamics of WM fibers with surgical outcomes. Materials and methods Pre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2919 |
| _version_ | 1797821226896326656 |
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| author | Yiwei Zhang Zhaoxi Liu Wanchen Dou Juan Wei Yuelei Lv Bo Hou Hui You Feng Feng |
| author_facet | Yiwei Zhang Zhaoxi Liu Wanchen Dou Juan Wei Yuelei Lv Bo Hou Hui You Feng Feng |
| author_sort | Yiwei Zhang |
| collection | DOAJ |
| description | Abstract Objectives To compare the white matter (WM) asymmetry in left and right medial temporal lobe epilepsy (mTLE) with and without hippocampal sclerosis (HS+, HS–) and assess the correlation of preoperative asymmetry and the dynamics of WM fibers with surgical outcomes. Materials and methods Preoperative MRI scans were collected from 58 mTLE patients (40 HS+, 18 HS–); 15 (11 HS+, 4 HS–) then underwent postoperative MRI scans. DTI parameters, including the fractional anisotropy (FA), mean diffusion coefficient (MD), axial diffusion coefficient (AD), and radial diffusion coefficient (RD), were extracted from 20 paired WM tracts by PANDA based on the JHU WM tractography atlas. The bilateral cerebral parameters and the pre‐ to postoperative changes in the DTI parameters of specific fiber tracts were compared. The asymmetry indexes (AIs) of paired fibers were also analyzed. Results There were fewer asymmetrical WM fibers in HS– patients than in HS+ patients. The pattern of WM asymmetry differed between left and right mTLE patients. Differences in the FA AI of the inferior fronto‐occipital fasciculus and inferior longitudinal fasciculus (ILF) were found in left HS+ patients with different surgical outcomes. All mTLE patients exhibited decreases in FA and increases in MD and RD in specific ipsilateral WM fibers. In International League Against Epilepsy (ILAE) grade 1 patients, the MD values in the ipsilateral CGH increased over time, whereas the RD values in the ipsilateral ILF and the AD values in the ipsilateral ILF and UNC decreased. In ILAE grade 2–5 patients, the FA values in the ipsilateral cingulate gyrus part of the cingulum (CGC) increased over time. Conclusion The WM tract asymmetry was more extensive in HS+ patients than in HS– patients. The preoperative WM fiber AIs in left HS+ patients may be useful for surgical prognosis. Additionally, pre‐ to postoperative changes in WM fibers may help predict surgical outcomes. |
| first_indexed | 2024-03-13T09:49:41Z |
| format | Article |
| id | doaj.art-8f0345c6af6047a682fce50893ae622f |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-13T09:49:41Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-8f0345c6af6047a682fce50893ae622f2023-05-24T14:27:20ZengWileyBrain and Behavior2162-32792023-04-01134n/an/a10.1002/brb3.2919Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imagingYiwei Zhang0Zhaoxi Liu1Wanchen Dou2Juan Wei3Yuelei Lv4Bo Hou5Hui You6Feng Feng7Department of Radiology Peking University First Hospital Beijing ChinaDepartment of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Neurosurgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing ChinaGE Healthcare, MR Research China Beijing ChinaDepartment of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract Objectives To compare the white matter (WM) asymmetry in left and right medial temporal lobe epilepsy (mTLE) with and without hippocampal sclerosis (HS+, HS–) and assess the correlation of preoperative asymmetry and the dynamics of WM fibers with surgical outcomes. Materials and methods Preoperative MRI scans were collected from 58 mTLE patients (40 HS+, 18 HS–); 15 (11 HS+, 4 HS–) then underwent postoperative MRI scans. DTI parameters, including the fractional anisotropy (FA), mean diffusion coefficient (MD), axial diffusion coefficient (AD), and radial diffusion coefficient (RD), were extracted from 20 paired WM tracts by PANDA based on the JHU WM tractography atlas. The bilateral cerebral parameters and the pre‐ to postoperative changes in the DTI parameters of specific fiber tracts were compared. The asymmetry indexes (AIs) of paired fibers were also analyzed. Results There were fewer asymmetrical WM fibers in HS– patients than in HS+ patients. The pattern of WM asymmetry differed between left and right mTLE patients. Differences in the FA AI of the inferior fronto‐occipital fasciculus and inferior longitudinal fasciculus (ILF) were found in left HS+ patients with different surgical outcomes. All mTLE patients exhibited decreases in FA and increases in MD and RD in specific ipsilateral WM fibers. In International League Against Epilepsy (ILAE) grade 1 patients, the MD values in the ipsilateral CGH increased over time, whereas the RD values in the ipsilateral ILF and the AD values in the ipsilateral ILF and UNC decreased. In ILAE grade 2–5 patients, the FA values in the ipsilateral cingulate gyrus part of the cingulum (CGC) increased over time. Conclusion The WM tract asymmetry was more extensive in HS+ patients than in HS– patients. The preoperative WM fiber AIs in left HS+ patients may be useful for surgical prognosis. Additionally, pre‐ to postoperative changes in WM fibers may help predict surgical outcomes.https://doi.org/10.1002/brb3.2919asymmetryDTImTLEsurgical outcomewhite matter fiber tract |
| spellingShingle | Yiwei Zhang Zhaoxi Liu Wanchen Dou Juan Wei Yuelei Lv Bo Hou Hui You Feng Feng Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging Brain and Behavior asymmetry DTI mTLE surgical outcome white matter fiber tract |
| title | Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| title_full | Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| title_fullStr | Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| title_full_unstemmed | Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| title_short | Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| title_sort | study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging |
| topic | asymmetry DTI mTLE surgical outcome white matter fiber tract |
| url | https://doi.org/10.1002/brb3.2919 |
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