Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography
In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The peri...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-10-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/13/10/13960 |
| _version_ | 1797999335199211520 |
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| author | Aritz Juarros Deitze Otaduy Josu Martinez-Perdiguero Aritz Retolaza Santos Merino |
| author_facet | Aritz Juarros Deitze Otaduy Josu Martinez-Perdiguero Aritz Retolaza Santos Merino |
| author_sort | Aritz Juarros |
| collection | DOAJ |
| description | In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices. |
| first_indexed | 2024-04-11T11:03:07Z |
| format | Article |
| id | doaj.art-8f036adbbcb44d21aa9dc33926f6e45f |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:03:07Z |
| publishDate | 2013-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-8f036adbbcb44d21aa9dc33926f6e45f2022-12-22T04:28:29ZengMDPI AGSensors1424-82202013-10-011310139601396810.3390/s131013960Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint LithographyAritz JuarrosDeitze OtaduyJosu Martinez-PerdigueroAritz RetolazaSantos MerinoIn this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.http://www.mdpi.com/1424-8220/13/10/13960label-freebiosensorsurface plasmon resonancenanohole arraynanoimprint lithography |
| spellingShingle | Aritz Juarros Deitze Otaduy Josu Martinez-Perdiguero Aritz Retolaza Santos Merino Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography Sensors label-free biosensor surface plasmon resonance nanohole array nanoimprint lithography |
| title | Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography |
| title_full | Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography |
| title_fullStr | Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography |
| title_full_unstemmed | Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography |
| title_short | Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography |
| title_sort | real time label free surface plasmon resonance biosensing with gold nanohole arrays fabricated by nanoimprint lithography |
| topic | label-free biosensor surface plasmon resonance nanohole array nanoimprint lithography |
| url | http://www.mdpi.com/1424-8220/13/10/13960 |
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