Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells
<p>Abstract</p> <p>Background</p> <p>We investigated the interaction of <it>Mycobacterium avium </it>subspecies <it>paratuberculosis, M. bovis </it>and <it>M. tuberculosis </it>and different glial cells (enteric glial and microglial c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-12-01
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| Series: | Gut Pathogens |
| Subjects: | |
| Online Access: | http://www.gutpathogens.com/content/3/1/19 |
| _version_ | 1811265940485046272 |
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| author | Cannas Sara Molicotti Paola Bua Alessandra Usai Donatella Sechi Leonardo A Scanu Antonio M Blasi Elisabetta Zanetti Stefania |
| author_facet | Cannas Sara Molicotti Paola Bua Alessandra Usai Donatella Sechi Leonardo A Scanu Antonio M Blasi Elisabetta Zanetti Stefania |
| author_sort | Cannas Sara |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We investigated the interaction of <it>Mycobacterium avium </it>subspecies <it>paratuberculosis, M. bovis </it>and <it>M. tuberculosis </it>and different glial cells (enteric glial and microglial cells) in order to evaluate the infecting ability of these microorganisms and the effects produced on these cells, such as the evaluation of cytokines expression.</p> <p>Results</p> <p>Our experiments demonstrated the adhesion of <it>M. paratuberculosis </it>to the enteroglial cells and the induction of IL-1A and IL-6 expression; <it>M. tuberculosis </it>and <it>M. bovis </it>showed a good adhesive capability to the enteric cell line with the expression of the following cytokines: IL-1A and IL-1B, TNF-α, G-CSF and GM-CSF; <it>M. bovis </it>induced the expression of IL-6 too.</p> <p>The experiment performed with the microglial cells confirmed the results obtained with the enteroglial cells after the infection with <it>M. tuberculosis </it>and <it>M. bovis</it>, whereas <it>M. paratuberculosis </it>stimulated the production of IL-1A and IL-1B.</p> <p>Conclusion</p> <p>Enteroglial and microglial cells, could be the target of pathogenic mycobacteria and, even if present in different locations (Enteric Nervous System and Central Nervous System), show to have similar mechanism of immunomodulation.</p> |
| first_indexed | 2024-04-12T20:33:00Z |
| format | Article |
| id | doaj.art-8f040afbec0a4e929db1ce1a01be625d |
| institution | Directory Open Access Journal |
| issn | 1757-4749 |
| language | English |
| last_indexed | 2024-04-12T20:33:00Z |
| publishDate | 2011-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Gut Pathogens |
| spelling | doaj.art-8f040afbec0a4e929db1ce1a01be625d2022-12-22T03:17:40ZengBMCGut Pathogens1757-47492011-12-01311910.1186/1757-4749-3-19Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cellsCannas SaraMolicotti PaolaBua AlessandraUsai DonatellaSechi Leonardo AScanu Antonio MBlasi ElisabettaZanetti Stefania<p>Abstract</p> <p>Background</p> <p>We investigated the interaction of <it>Mycobacterium avium </it>subspecies <it>paratuberculosis, M. bovis </it>and <it>M. tuberculosis </it>and different glial cells (enteric glial and microglial cells) in order to evaluate the infecting ability of these microorganisms and the effects produced on these cells, such as the evaluation of cytokines expression.</p> <p>Results</p> <p>Our experiments demonstrated the adhesion of <it>M. paratuberculosis </it>to the enteroglial cells and the induction of IL-1A and IL-6 expression; <it>M. tuberculosis </it>and <it>M. bovis </it>showed a good adhesive capability to the enteric cell line with the expression of the following cytokines: IL-1A and IL-1B, TNF-α, G-CSF and GM-CSF; <it>M. bovis </it>induced the expression of IL-6 too.</p> <p>The experiment performed with the microglial cells confirmed the results obtained with the enteroglial cells after the infection with <it>M. tuberculosis </it>and <it>M. bovis</it>, whereas <it>M. paratuberculosis </it>stimulated the production of IL-1A and IL-1B.</p> <p>Conclusion</p> <p>Enteroglial and microglial cells, could be the target of pathogenic mycobacteria and, even if present in different locations (Enteric Nervous System and Central Nervous System), show to have similar mechanism of immunomodulation.</p>http://www.gutpathogens.com/content/3/1/19Mycobacteriaenteric glial cellsmicrogliacytokines |
| spellingShingle | Cannas Sara Molicotti Paola Bua Alessandra Usai Donatella Sechi Leonardo A Scanu Antonio M Blasi Elisabetta Zanetti Stefania Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells Gut Pathogens Mycobacteria enteric glial cells microglia cytokines |
| title | Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells |
| title_full | Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells |
| title_fullStr | Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells |
| title_full_unstemmed | Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells |
| title_short | Interaction between <it>Mycobacterium tuberculosis</it>, <it>Mycobacterium bovis</it>, <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>with the enteric glia and microglial cells |
| title_sort | interaction between it mycobacterium tuberculosis it it mycobacterium bovis it it mycobacterium avium it subspecies it paratuberculosis it with the enteric glia and microglial cells |
| topic | Mycobacteria enteric glial cells microglia cytokines |
| url | http://www.gutpathogens.com/content/3/1/19 |
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