Small Molecule Inhibitors of Ceramidases
The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention. Although until recently on...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2014-06-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/362995 |
| _version_ | 1828335503203631104 |
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| author | Essa M. Saied Christoph Arenz |
| author_facet | Essa M. Saied Christoph Arenz |
| author_sort | Essa M. Saied |
| collection | DOAJ |
| description | The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention. Although until recently only moderately active inhibitors have been described, first in vivo experiments suggest activity against cancer cell survival and multi-drug resistance. Here, we provide a brief overview on the different ceramidases, and we will review the known inhibitors and current strategies for further inhibitor development. |
| first_indexed | 2024-04-13T21:48:08Z |
| format | Article |
| id | doaj.art-8f04dba23c8042bd9ad9e3db8185c397 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-13T21:48:08Z |
| publishDate | 2014-06-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-8f04dba23c8042bd9ad9e3db8185c3972022-12-22T02:28:30ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782014-06-0134119721210.1159/000362995362995Small Molecule Inhibitors of CeramidasesEssa M. SaiedChristoph ArenzThe equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention. Although until recently only moderately active inhibitors have been described, first in vivo experiments suggest activity against cancer cell survival and multi-drug resistance. Here, we provide a brief overview on the different ceramidases, and we will review the known inhibitors and current strategies for further inhibitor development.http://www.karger.com/Article/FullText/362995CeramideEnzyme inhibitorsEnzyme assaysLipid probesCeramidasesSphingolipidsLipid signaling |
| spellingShingle | Essa M. Saied Christoph Arenz Small Molecule Inhibitors of Ceramidases Cellular Physiology and Biochemistry Ceramide Enzyme inhibitors Enzyme assays Lipid probes Ceramidases Sphingolipids Lipid signaling |
| title | Small Molecule Inhibitors of Ceramidases |
| title_full | Small Molecule Inhibitors of Ceramidases |
| title_fullStr | Small Molecule Inhibitors of Ceramidases |
| title_full_unstemmed | Small Molecule Inhibitors of Ceramidases |
| title_short | Small Molecule Inhibitors of Ceramidases |
| title_sort | small molecule inhibitors of ceramidases |
| topic | Ceramide Enzyme inhibitors Enzyme assays Lipid probes Ceramidases Sphingolipids Lipid signaling |
| url | http://www.karger.com/Article/FullText/362995 |
| work_keys_str_mv | AT essamsaied smallmoleculeinhibitorsofceramidases AT christopharenz smallmoleculeinhibitorsofceramidases |