Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma
Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity in which patient prognosis and treatment primarily depend upon histological grading and clinical staging. Tumor budding has been recognized as a morphological marker of tumor invasion, which rep...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Orofacial Sciences |
| Subjects: | |
| Online Access: | http://www.jofs.in/article.asp?issn=0975-8844;year=2023;volume=15;issue=2;spage=160;epage=166;aulast=Selvaraj |
| _version_ | 1827345098275291136 |
|---|---|
| author | Freeda Mary Selvaraj Varun Raghavan Pillai Anna Palliath Joseph Prathiba Ramani Jayanthi Pazhani Vinod Mony |
| author_facet | Freeda Mary Selvaraj Varun Raghavan Pillai Anna Palliath Joseph Prathiba Ramani Jayanthi Pazhani Vinod Mony |
| author_sort | Freeda Mary Selvaraj |
| collection | DOAJ |
| description | Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity in which patient prognosis and treatment primarily depend upon histological grading and clinical staging. Tumor budding has been recognized as a morphological marker of tumor invasion, which represents an aggressive feature of epithelial malignancies. This study was done to assess the activity of tumor budding in different grades of OSCC. Materials and Methods: An immunohistochemical study was performed on tissue sections obtained from 30 paraffin-embedded blocks of clinically and histologically diagnosed cases of OSCC. The sections were stained with pan cytokeratin and observed under high-power magnification. Tumor budding activity and cell nest size were assessed in different grades of OSCC. Results: A significant correlation was observed between tumor budding and cell nest size in OSCC. Conclusion: This study suggests the importance of using tumor buds as an additional parameter in the diagnosis and grading of OSCC. |
| first_indexed | 2024-03-07T23:00:16Z |
| format | Article |
| id | doaj.art-8f066b1e436a44aabd2b99911df8a735 |
| institution | Directory Open Access Journal |
| issn | 0975-8844 |
| language | English |
| last_indexed | 2024-03-07T23:00:16Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orofacial Sciences |
| spelling | doaj.art-8f066b1e436a44aabd2b99911df8a7352024-02-22T15:03:50ZengWolters Kluwer Medknow PublicationsJournal of Orofacial Sciences0975-88442023-01-0115216016610.4103/jofs.jofs_311_23Assessment of Tumor Budding in Different Grades of Oral Squamous Cell CarcinomaFreeda Mary SelvarajVarun Raghavan PillaiAnna Palliath JosephPrathiba RamaniJayanthi PazhaniVinod MonyIntroduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity in which patient prognosis and treatment primarily depend upon histological grading and clinical staging. Tumor budding has been recognized as a morphological marker of tumor invasion, which represents an aggressive feature of epithelial malignancies. This study was done to assess the activity of tumor budding in different grades of OSCC. Materials and Methods: An immunohistochemical study was performed on tissue sections obtained from 30 paraffin-embedded blocks of clinically and histologically diagnosed cases of OSCC. The sections were stained with pan cytokeratin and observed under high-power magnification. Tumor budding activity and cell nest size were assessed in different grades of OSCC. Results: A significant correlation was observed between tumor budding and cell nest size in OSCC. Conclusion: This study suggests the importance of using tumor buds as an additional parameter in the diagnosis and grading of OSCC.http://www.jofs.in/article.asp?issn=0975-8844;year=2023;volume=15;issue=2;spage=160;epage=166;aulast=Selvarajgradingoral squamous cell carcinomatumor budding |
| spellingShingle | Freeda Mary Selvaraj Varun Raghavan Pillai Anna Palliath Joseph Prathiba Ramani Jayanthi Pazhani Vinod Mony Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma Journal of Orofacial Sciences grading oral squamous cell carcinoma tumor budding |
| title | Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma |
| title_full | Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma |
| title_fullStr | Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma |
| title_short | Assessment of Tumor Budding in Different Grades of Oral Squamous Cell Carcinoma |
| title_sort | assessment of tumor budding in different grades of oral squamous cell carcinoma |
| topic | grading oral squamous cell carcinoma tumor budding |
| url | http://www.jofs.in/article.asp?issn=0975-8844;year=2023;volume=15;issue=2;spage=160;epage=166;aulast=Selvaraj |
| work_keys_str_mv | AT freedamaryselvaraj assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma AT varunraghavanpillai assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma AT annapalliathjoseph assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma AT prathibaramani assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma AT jayanthipazhani assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma AT vinodmony assessmentoftumorbuddingindifferentgradesoforalsquamouscellcarcinoma |