Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues
Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised t...
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MDPI AG
2023-09-01
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Series: | Biosensors |
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Online Access: | https://www.mdpi.com/2079-6374/13/10/900 |
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author | Antonio Velarte Aranzazu Otin Pablo Giménez-Gómez Xavier Muñoz-Berbel Esther Pueyo |
author_facet | Antonio Velarte Aranzazu Otin Pablo Giménez-Gómez Xavier Muñoz-Berbel Esther Pueyo |
author_sort | Antonio Velarte |
collection | DOAJ |
description | Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of ∼1 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m), enabling the tissue to be bathed in any medium within the system. |
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format | Article |
id | doaj.art-8f07389742a04d2aa1013adcdc9ba34e |
institution | Directory Open Access Journal |
issn | 2079-6374 |
language | English |
last_indexed | 2024-03-10T21:23:40Z |
publishDate | 2023-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Biosensors |
spelling | doaj.art-8f07389742a04d2aa1013adcdc9ba34e2023-11-19T15:51:03ZengMDPI AGBiosensors2079-63742023-09-01131090010.3390/bios13100900Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised TissuesAntonio Velarte0Aranzazu Otin1Pablo Giménez-Gómez2Xavier Muñoz-Berbel3Esther Pueyo4Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, I3A Institute, IIS Aragón, University of Zaragoza, 50018 Zaragoza, SpainGrupo de Electrónica de Potencia y Microelectrónica (GEPM) Group, I3A Institute, University of Zaragoza, 50018 Zaragoza, SpainDepartment of Materials and Environmental Chemistry, Stockholm University, 106 91 Stockholm, SwedenInstituto de Microelectrónica de Barcelona (IMB-CNM), Consejo Superior de Investigaciones Científicas (CSIC), Campus UAB, 08193 Cerdanyola del Vallès, SpainBiomedical Signal Interpretation and Computational Simulation (BSICoS) Group, I3A Institute, IIS Aragón, University of Zaragoza, 50018 Zaragoza, SpainCardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of ∼1 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>m), enabling the tissue to be bathed in any medium within the system.https://www.mdpi.com/2079-6374/13/10/900biosensorsstretch sensorexcised tissuesPOFcardiac |
spellingShingle | Antonio Velarte Aranzazu Otin Pablo Giménez-Gómez Xavier Muñoz-Berbel Esther Pueyo Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues Biosensors biosensors stretch sensor excised tissues POF cardiac |
title | Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues |
title_full | Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues |
title_fullStr | Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues |
title_full_unstemmed | Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues |
title_short | Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues |
title_sort | fiber optic based system for high resolution monitoring of stretch in excised tissues |
topic | biosensors stretch sensor excised tissues POF cardiac |
url | https://www.mdpi.com/2079-6374/13/10/900 |
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