Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management
Giacomo Calini,1– 4 Mohamed A Abd El Aziz,1,5 Lucia Paolini,6 Solafah Abdalla,1,7 Matteo Rottoli,3,4 Giulio Mari,8 David W Larson1 1Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA; 2Department of Medical Area, University of Udine, Udine, Italy; 3Surgery of the Alimentary Tract,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Clinical and Experimental Gastroenterology |
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| Online Access: | https://www.dovepress.com/symptomatic-uncomplicated-diverticular-disease-sudd-practical-guidance-peer-reviewed-fulltext-article-CEG |
| _version_ | 1797858296275664896 |
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| author | Calini G Abd El Aziz MA Paolini L Abdalla S Rottoli M Mari G Larson DW |
| author_facet | Calini G Abd El Aziz MA Paolini L Abdalla S Rottoli M Mari G Larson DW |
| author_sort | Calini G |
| collection | DOAJ |
| description | Giacomo Calini,1– 4 Mohamed A Abd El Aziz,1,5 Lucia Paolini,6 Solafah Abdalla,1,7 Matteo Rottoli,3,4 Giulio Mari,8 David W Larson1 1Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA; 2Department of Medical Area, University of Udine, Udine, Italy; 3Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy; 5Internal Medicine Department, MercyOne North Iowa, Mason City, IA, USA; 6Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano Bicocca, Monza, Italy; 7Department of Oncologic and Digestive Surgery, Le Kremlin-Bicêtre University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France; 8Department of Laparoscopic and Oncological General Surgery, ASST Brianza, Desio Hospital, Desio, ItalyCorrespondence: Giacomo Calini, Research Collaborator, Colon and Rectal Surgery Division, Department of Surgery - Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA, Email giacomo.calini@gmail.com; Calini.Giacomo@mayo.eduAbstract: Symptomatic Uncomplicated Diverticular Disease (SUDD) is a syndrome within the diverticular disease spectrum, characterized by local abdominal pain with bowel movement changes but without systemic inflammation. This narrative review reports current knowledge, delivers practical guidance, and reveals challenges for the clinical management of SUDD. A broad and common consensus on the definition of SUDD is still needed. However, it is mainly considered a chronic condition that impairs quality of life (QoL) and is characterized by persistent left lower quadrant abdominal pain with bowel movement changes (eg, diarrhea) and low-grade inflammation (eg, elevated calprotectin) but without systemic inflammation. Age, genetic predisposition, obesity, physical inactivity, low-fiber diet, and smoking are considered risk factors. The pathogenesis of SUDD is not entirely clarified. It seems to result from an interaction between fecal microbiota alterations, neuro-immune enteric interactions, and muscular system dysfunction associated with a low-grade and local inflammatory state. At diagnosis, it is essential to assess baseline clinical and Quality of Life (QoL) scores to evaluate treatment efficacy and, ideally, to enroll patients in cohort studies, clinical trials, or registries. SUDD treatments aim to improve symptoms and QoL, prevent recurrence, and avoid disease progression and complications. An overall healthy lifestyle – physical activity and a high-fiber diet, with a focus on whole grains, fruits, and vegetables – is encouraged. Probiotics could effectively reduce symptoms in patients with SUDD, but their utility is missing adequate evidence. Using Rifaximin plus fiber and Mesalazine offers potential in controlling symptoms in patients with SUDD and might prevent acute diverticulitis. Surgery could be considered in patients with medical treatment failure and persistently impaired QoL. Still, studies with well-defined diagnostic criteria for SUDD that evaluate the safety, QoL, effectiveness, and cost-effectiveness of these interventions using standard scores and comparable outcomes are needed.Keywords: colonic diverticulosis, diverticulitis, irritable bowel syndrome, microbiota, treatment, probiotic |
| first_indexed | 2024-04-09T21:11:03Z |
| format | Article |
| id | doaj.art-8f0a1712e76a47e6b344046676a67a81 |
| institution | Directory Open Access Journal |
| issn | 1178-7023 |
| language | English |
| last_indexed | 2024-04-09T21:11:03Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj.art-8f0a1712e76a47e6b344046676a67a812023-03-28T18:02:02ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232023-03-01Volume 16294382605Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical ManagementCalini GAbd El Aziz MAPaolini LAbdalla SRottoli MMari GLarson DWGiacomo Calini,1– 4 Mohamed A Abd El Aziz,1,5 Lucia Paolini,6 Solafah Abdalla,1,7 Matteo Rottoli,3,4 Giulio Mari,8 David W Larson1 1Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA; 2Department of Medical Area, University of Udine, Udine, Italy; 3Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy; 5Internal Medicine Department, MercyOne North Iowa, Mason City, IA, USA; 6Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano Bicocca, Monza, Italy; 7Department of Oncologic and Digestive Surgery, Le Kremlin-Bicêtre University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France; 8Department of Laparoscopic and Oncological General Surgery, ASST Brianza, Desio Hospital, Desio, ItalyCorrespondence: Giacomo Calini, Research Collaborator, Colon and Rectal Surgery Division, Department of Surgery - Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA, Email giacomo.calini@gmail.com; Calini.Giacomo@mayo.eduAbstract: Symptomatic Uncomplicated Diverticular Disease (SUDD) is a syndrome within the diverticular disease spectrum, characterized by local abdominal pain with bowel movement changes but without systemic inflammation. This narrative review reports current knowledge, delivers practical guidance, and reveals challenges for the clinical management of SUDD. A broad and common consensus on the definition of SUDD is still needed. However, it is mainly considered a chronic condition that impairs quality of life (QoL) and is characterized by persistent left lower quadrant abdominal pain with bowel movement changes (eg, diarrhea) and low-grade inflammation (eg, elevated calprotectin) but without systemic inflammation. Age, genetic predisposition, obesity, physical inactivity, low-fiber diet, and smoking are considered risk factors. The pathogenesis of SUDD is not entirely clarified. It seems to result from an interaction between fecal microbiota alterations, neuro-immune enteric interactions, and muscular system dysfunction associated with a low-grade and local inflammatory state. At diagnosis, it is essential to assess baseline clinical and Quality of Life (QoL) scores to evaluate treatment efficacy and, ideally, to enroll patients in cohort studies, clinical trials, or registries. SUDD treatments aim to improve symptoms and QoL, prevent recurrence, and avoid disease progression and complications. An overall healthy lifestyle – physical activity and a high-fiber diet, with a focus on whole grains, fruits, and vegetables – is encouraged. Probiotics could effectively reduce symptoms in patients with SUDD, but their utility is missing adequate evidence. Using Rifaximin plus fiber and Mesalazine offers potential in controlling symptoms in patients with SUDD and might prevent acute diverticulitis. Surgery could be considered in patients with medical treatment failure and persistently impaired QoL. Still, studies with well-defined diagnostic criteria for SUDD that evaluate the safety, QoL, effectiveness, and cost-effectiveness of these interventions using standard scores and comparable outcomes are needed.Keywords: colonic diverticulosis, diverticulitis, irritable bowel syndrome, microbiota, treatment, probiotichttps://www.dovepress.com/symptomatic-uncomplicated-diverticular-disease-sudd-practical-guidance-peer-reviewed-fulltext-article-CEGcolonic diverticulosisdiverticulitisirritable bowel syndromemicrobiotatreatmentprobiotic; |
| spellingShingle | Calini G Abd El Aziz MA Paolini L Abdalla S Rottoli M Mari G Larson DW Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management Clinical and Experimental Gastroenterology colonic diverticulosis diverticulitis irritable bowel syndrome microbiota treatment probiotic; |
| title | Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management |
| title_full | Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management |
| title_fullStr | Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management |
| title_full_unstemmed | Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management |
| title_short | Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management |
| title_sort | symptomatic uncomplicated diverticular disease sudd practical guidance and challenges for clinical management |
| topic | colonic diverticulosis diverticulitis irritable bowel syndrome microbiota treatment probiotic; |
| url | https://www.dovepress.com/symptomatic-uncomplicated-diverticular-disease-sudd-practical-guidance-peer-reviewed-fulltext-article-CEG |
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