Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy
Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1868266 |
| _version_ | 1797677090702622720 |
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| author | Aitziber Buqué Lorenzo Galluzzi Guido Kroemer |
| author_facet | Aitziber Buqué Lorenzo Galluzzi Guido Kroemer |
| author_sort | Aitziber Buqué |
| collection | DOAJ |
| description | Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis. |
| first_indexed | 2024-03-11T22:40:00Z |
| format | Article |
| id | doaj.art-8f0a7284b48541809b991914277f7a5f |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:00Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-8f0a7284b48541809b991914277f7a5f2023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-01-018110.1080/23723556.2020.18682661868266Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapyAitziber Buqué0Lorenzo Galluzzi1Guido Kroemer2Weill Cornell Medical CollegeWeill Cornell Medical CollegeUniversité de Paris, Sorbonne UniversitéCarbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.http://dx.doi.org/10.1080/23723556.2020.18682663-hydroxybutyratectla4ketogenic dietimmune checkpoint inhibitorspd-1sucrose |
| spellingShingle | Aitziber Buqué Lorenzo Galluzzi Guido Kroemer Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy Molecular & Cellular Oncology 3-hydroxybutyrate ctla4 ketogenic diet immune checkpoint inhibitors pd-1 sucrose |
| title | Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy |
| title_full | Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy |
| title_fullStr | Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy |
| title_full_unstemmed | Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy |
| title_short | Ketosis versus carbotoxicity – metabolism determines the outcome of cancer immunotherapy |
| title_sort | ketosis versus carbotoxicity metabolism determines the outcome of cancer immunotherapy |
| topic | 3-hydroxybutyrate ctla4 ketogenic diet immune checkpoint inhibitors pd-1 sucrose |
| url | http://dx.doi.org/10.1080/23723556.2020.1868266 |
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