Smarter vaccine design will circumvent regulatory T cell-mediated evasion in chronic HIV and HCV infection

Smarter vaccine design will circumvent regulatory T cell-mediated evasion in chronic HIV and HCV infection

Despite years of research, vaccines against HIV and HCV are not yet available, due largely to effective viral immunoevasive mechanisms. A novel escape mechanism observed in viruses that cause chronic infection is suppression of viral-specific effector CD4+ and CD8+ T cells by stimulating regulatory...

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Bibliographic Details
Main Authors: Anne Searls De Groot, Leonard eMoise, Frances eTerry, Andres H. Gutierrez, Ryan eTassone, Phyllis eLosikoff, Stephen H. Gregory, Chris eBailey-Kellogg, William D Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Microbiology
Subjects:
HIV
HLA-DR Antigens
Immune Evasion
Vaccines
immunoinformatics
regulatory T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00502/full

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