Error‐related brain activity associated with obsessive–compulsive symptoms in youth
Abstract Background Subclinical obsessive–compulsive symptoms (OCS) are common in children, and increase risk for later onset of obsessive–compulsive disorder (OCD). In pediatric patients with OCD, neuroimaging research implicates altered neural mechanisms for error‐processing, but whether abnormal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2941 |
| _version_ | 1797821227121770496 |
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| author | Hannah Becker Yanni Liu Gregory L. Hanna Emily Bilek Stefanie Russman Block Jillian E. Hardee Mary M. Heitzeg David Pagliaccio Rachel Marsh Kate D. Fitzgerald |
| author_facet | Hannah Becker Yanni Liu Gregory L. Hanna Emily Bilek Stefanie Russman Block Jillian E. Hardee Mary M. Heitzeg David Pagliaccio Rachel Marsh Kate D. Fitzgerald |
| author_sort | Hannah Becker |
| collection | DOAJ |
| description | Abstract Background Subclinical obsessive–compulsive symptoms (OCS) are common in children, and increase risk for later onset of obsessive–compulsive disorder (OCD). In pediatric patients with OCD, neuroimaging research implicates altered neural mechanisms for error‐processing, but whether abnormal brain response occurs with subclinical OCS remains poorly understood. Methods Using functional magnetic resonance imaging (fMRI), 113 youth (8–18 years; 45 female) from a community sample were scanned during an error‐eliciting Go/No‐Go task. OCS were assessed dimensionally using the obsessive–compulsive subscale of the Child Behavior Checklist. The association between OCS scores and error‐related brain activity was examined at the whole‐brain level. Results Lower OCS scores associated with stronger response to errors in dorsal anterior cingulate cortex (dACC), caudate, putamen, thalamus, and occipital cortex. Additionally, lower OCS related to higher capacity for inhibitory control, as indexed by greater accuracy on No‐Go trials during fMRI scanning. The relationship between lower OCS and better accuracy on No‐Go trials was mediated by greater error‐related dACC activity. Conclusions The inverse relationship between OCS and error‐related activity in the dACC and extended cortical–striatal–thalamic circuitry may index an adaptive process by which subclinical OCS are minimized in youth. Further, these results identify an observable pattern of brain activity that tracks with subclinical OCS severity. Understanding the link between neural networks for error processing and the normal to abnormal range of OCS may pave the way for brain‐based strategies to identify children who are more likely to develop OCD and enable the targeting of preventive strategies to reduce risk. |
| first_indexed | 2024-03-13T09:49:41Z |
| format | Article |
| id | doaj.art-8f0abcee616e45c294de97061f7e5fcb |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-13T09:49:41Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-8f0abcee616e45c294de97061f7e5fcb2023-05-24T14:27:20ZengWileyBrain and Behavior2162-32792023-04-01134n/an/a10.1002/brb3.2941Error‐related brain activity associated with obsessive–compulsive symptoms in youthHannah Becker0Yanni Liu1Gregory L. Hanna2Emily Bilek3Stefanie Russman Block4Jillian E. Hardee5Mary M. Heitzeg6David Pagliaccio7Rachel Marsh8Kate D. Fitzgerald9Department of Psychology, University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USANew York State Psychiatric Institute Columbia University New York New York USANew York State Psychiatric Institute Columbia University New York New York USANew York State Psychiatric Institute Columbia University New York New York USAAbstract Background Subclinical obsessive–compulsive symptoms (OCS) are common in children, and increase risk for later onset of obsessive–compulsive disorder (OCD). In pediatric patients with OCD, neuroimaging research implicates altered neural mechanisms for error‐processing, but whether abnormal brain response occurs with subclinical OCS remains poorly understood. Methods Using functional magnetic resonance imaging (fMRI), 113 youth (8–18 years; 45 female) from a community sample were scanned during an error‐eliciting Go/No‐Go task. OCS were assessed dimensionally using the obsessive–compulsive subscale of the Child Behavior Checklist. The association between OCS scores and error‐related brain activity was examined at the whole‐brain level. Results Lower OCS scores associated with stronger response to errors in dorsal anterior cingulate cortex (dACC), caudate, putamen, thalamus, and occipital cortex. Additionally, lower OCS related to higher capacity for inhibitory control, as indexed by greater accuracy on No‐Go trials during fMRI scanning. The relationship between lower OCS and better accuracy on No‐Go trials was mediated by greater error‐related dACC activity. Conclusions The inverse relationship between OCS and error‐related activity in the dACC and extended cortical–striatal–thalamic circuitry may index an adaptive process by which subclinical OCS are minimized in youth. Further, these results identify an observable pattern of brain activity that tracks with subclinical OCS severity. Understanding the link between neural networks for error processing and the normal to abnormal range of OCS may pave the way for brain‐based strategies to identify children who are more likely to develop OCD and enable the targeting of preventive strategies to reduce risk.https://doi.org/10.1002/brb3.2941community sampledimensional approachdorsal anterior cingulate cortexerror processingobsessive–compulsive symptomsyouth |
| spellingShingle | Hannah Becker Yanni Liu Gregory L. Hanna Emily Bilek Stefanie Russman Block Jillian E. Hardee Mary M. Heitzeg David Pagliaccio Rachel Marsh Kate D. Fitzgerald Error‐related brain activity associated with obsessive–compulsive symptoms in youth Brain and Behavior community sample dimensional approach dorsal anterior cingulate cortex error processing obsessive–compulsive symptoms youth |
| title | Error‐related brain activity associated with obsessive–compulsive symptoms in youth |
| title_full | Error‐related brain activity associated with obsessive–compulsive symptoms in youth |
| title_fullStr | Error‐related brain activity associated with obsessive–compulsive symptoms in youth |
| title_full_unstemmed | Error‐related brain activity associated with obsessive–compulsive symptoms in youth |
| title_short | Error‐related brain activity associated with obsessive–compulsive symptoms in youth |
| title_sort | error related brain activity associated with obsessive compulsive symptoms in youth |
| topic | community sample dimensional approach dorsal anterior cingulate cortex error processing obsessive–compulsive symptoms youth |
| url | https://doi.org/10.1002/brb3.2941 |
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