BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

Abstract Background Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption. However, the mechanisms underlying the tight regula...

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Bibliographic Details
Main Authors: Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell & Bioscience
Subjects:
BHLHE40
NFATc1
c-Fos
Osteoclast
Bone Resorption
Online Access:https://doi.org/10.1186/s13578-022-00813-7

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