Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2
Breast cancer: A protein to target for double effect A new way to treat some forms of breast cancer might be achieved by drugs that interact with a cell surface protein that binds to growth hormone and transmits growth-inducing signals into the cells. Rajkumar Lakshmanaswamy and colleagues at Texas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0197-8 |
| _version_ | 1818857424666230784 |
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| author | Arunkumar Arumugam Ramadevi Subramani Sushmita Bose Nandy Daniel Terreros Alok Kumar Dwivedi Edward Saltzstein Rajkumar Lakshmanaswamy |
| author_facet | Arunkumar Arumugam Ramadevi Subramani Sushmita Bose Nandy Daniel Terreros Alok Kumar Dwivedi Edward Saltzstein Rajkumar Lakshmanaswamy |
| author_sort | Arunkumar Arumugam |
| collection | DOAJ |
| description | Breast cancer: A protein to target for double effect A new way to treat some forms of breast cancer might be achieved by drugs that interact with a cell surface protein that binds to growth hormone and transmits growth-inducing signals into the cells. Rajkumar Lakshmanaswamy and colleagues at Texas Tech University, El Paso, USA, investigated the role of growth hormone receptor (GHR) protein in human breast cancer cells. Silencing the gene for GHR dramatically reduced the ability of the cells to multiply and spread, and also reduced the cells’ resistance to anti-cancer drugs. Increasing the activity of the GHR gene increased the cells’ cancerous activity and their resistance to chemotherapy. The research identified some molecular signaling pathways inside cells that mediated these effects. Drugs interfering with GHR activity might inhibit the spread of cancer while making existing cancer cells more susceptible to treatment. |
| first_indexed | 2024-12-19T08:40:11Z |
| format | Article |
| id | doaj.art-8f0af18cfc0940eaa10f832ee755c732 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-19T08:40:11Z |
| publishDate | 2019-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-8f0af18cfc0940eaa10f832ee755c7322022-12-21T20:28:57ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-01-0151111310.1038/s12276-018-0197-8Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2Arunkumar Arumugam0Ramadevi Subramani1Sushmita Bose Nandy2Daniel Terreros3Alok Kumar Dwivedi4Edward Saltzstein5Rajkumar Lakshmanaswamy6Center of Emphasis in Cancer Research, Texas Tech University Health Sciences Center El PasoCenter of Emphasis in Cancer Research, Texas Tech University Health Sciences Center El PasoCenter of Emphasis in Cancer Research, Texas Tech University Health Sciences Center El PasoResearch Core Laboratory, Texas Tech University Health Sciences Center El PasoDivision of Biostatistics & Epidemiology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoUniversity Breast Care Center, Texas Tech University Health Sciences Center El PasoCenter of Emphasis in Cancer Research, Texas Tech University Health Sciences Center El PasoBreast cancer: A protein to target for double effect A new way to treat some forms of breast cancer might be achieved by drugs that interact with a cell surface protein that binds to growth hormone and transmits growth-inducing signals into the cells. Rajkumar Lakshmanaswamy and colleagues at Texas Tech University, El Paso, USA, investigated the role of growth hormone receptor (GHR) protein in human breast cancer cells. Silencing the gene for GHR dramatically reduced the ability of the cells to multiply and spread, and also reduced the cells’ resistance to anti-cancer drugs. Increasing the activity of the GHR gene increased the cells’ cancerous activity and their resistance to chemotherapy. The research identified some molecular signaling pathways inside cells that mediated these effects. Drugs interfering with GHR activity might inhibit the spread of cancer while making existing cancer cells more susceptible to treatment.https://doi.org/10.1038/s12276-018-0197-8 |
| spellingShingle | Arunkumar Arumugam Ramadevi Subramani Sushmita Bose Nandy Daniel Terreros Alok Kumar Dwivedi Edward Saltzstein Rajkumar Lakshmanaswamy Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 Experimental and Molecular Medicine |
| title | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 |
| title_full | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 |
| title_fullStr | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 |
| title_full_unstemmed | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 |
| title_short | Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 |
| title_sort | silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through atp binding cassette sub family g member 2 |
| url | https://doi.org/10.1038/s12276-018-0197-8 |
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