Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies
Burst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/2/132 |
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| author | Siriporn Okonogi Adchareeya Kaewpinta Sakornrat Khongkhunthian Pisaisit Chaijareenont |
| author_facet | Siriporn Okonogi Adchareeya Kaewpinta Sakornrat Khongkhunthian Pisaisit Chaijareenont |
| author_sort | Siriporn Okonogi |
| collection | DOAJ |
| description | Burst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP solid dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was found that carrier type and the ratio of CP to carrier affected drug crystallinity. Nanoemulsions formulated from the optimized CP solid dispersions were used to prepare CP-NG. It was found that the ratio of drug to carrier in CP solid dispersions affected the particle size and zeta potential of the nanoemulsions as well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release from CP-NG followed a first-order kinetic reaction and the release mechanism was an anomalous transport. Drug release rate decreased with an increase in solid dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of CP to the polymer mixture is suitable for sustaining drug release with high tooth bleaching efficacy and without reduction of enamel microhardness. The developed CP-NG is a promising potential tooth bleaching formulation. |
| first_indexed | 2024-03-09T05:17:19Z |
| format | Article |
| id | doaj.art-8f0b8ba85a4840ed97d805b718d53c21 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T05:17:19Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-8f0b8ba85a4840ed97d805b718d53c212023-12-03T12:44:48ZengMDPI AGPharmaceuticals1424-82472021-02-0114213210.3390/ph14020132Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo StudiesSiriporn Okonogi0Adchareeya Kaewpinta1Sakornrat Khongkhunthian2Pisaisit Chaijareenont3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInterdisciplinary Program in Nanoscience and Nanotechnology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200, ThailandBurst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP solid dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was found that carrier type and the ratio of CP to carrier affected drug crystallinity. Nanoemulsions formulated from the optimized CP solid dispersions were used to prepare CP-NG. It was found that the ratio of drug to carrier in CP solid dispersions affected the particle size and zeta potential of the nanoemulsions as well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release from CP-NG followed a first-order kinetic reaction and the release mechanism was an anomalous transport. Drug release rate decreased with an increase in solid dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of CP to the polymer mixture is suitable for sustaining drug release with high tooth bleaching efficacy and without reduction of enamel microhardness. The developed CP-NG is a promising potential tooth bleaching formulation.https://www.mdpi.com/1424-8247/14/2/132carbamide peroxidesolid dispersionnanoemulsionnanoemulgelcontrolled releasetooth bleaching efficacy |
| spellingShingle | Siriporn Okonogi Adchareeya Kaewpinta Sakornrat Khongkhunthian Pisaisit Chaijareenont Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies Pharmaceuticals carbamide peroxide solid dispersion nanoemulsion nanoemulgel controlled release tooth bleaching efficacy |
| title | Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies |
| title_full | Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies |
| title_fullStr | Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies |
| title_full_unstemmed | Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies |
| title_short | Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies |
| title_sort | development of controlled release carbamide peroxide loaded nanoemulgel for tooth bleaching in vitro and ex vivo studies |
| topic | carbamide peroxide solid dispersion nanoemulsion nanoemulgel controlled release tooth bleaching efficacy |
| url | https://www.mdpi.com/1424-8247/14/2/132 |
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