Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis
Rhabdomyosarcomas are among the most common soft-tissue tumors in children. These tumors are derived from mesenchymal tissue with a tendency toward myogenic differentiation that probably originates from immature and highly invasive satellite cells associated with the embryogenesis of skeletal muscle...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-01-01
|
| Series: | Clinics and Practice |
| Subjects: | |
| Online Access: | https://www.clinicsandpractice.org/index.php/cp/article/view/429 |
| _version_ | 1798025982763859968 |
|---|---|
| author | Madhusudan Astekar Rashmi Metgud Priyanka Sharma Gayatri Ramesh |
| author_facet | Madhusudan Astekar Rashmi Metgud Priyanka Sharma Gayatri Ramesh |
| author_sort | Madhusudan Astekar |
| collection | DOAJ |
| description | Rhabdomyosarcomas are among the most common soft-tissue tumors in children. These tumors are derived from mesenchymal tissue with a tendency toward myogenic differentiation that probably originates from immature and highly invasive satellite cells associated with the embryogenesis of skeletal muscle. Some of these tumors are associated with high rates of recurrence and metastasis. The diagnosis is made by microscopic analysis and auxiliary techniques such as immunohistochemistry, electron microscopy, cytogenetic analysis, and molecular biology. We report a case of 28- year-old man who presented with a painless progressive swelling of gingiva since 3 months, which was gradually increasing in size without any systemic symptoms or signs of any metastatic spread. An incisional biopsy was done and histopathology reported an alveolar variant of rhabdomyosarcoma. Immuno - histochemistry with panel of markers was done which showed positivity for CD99, vimentin and negative for desmin and myogenin. So the characteristic immunohistological expression was negative in present case. Hence we conclude that haematoxylin and eosin morphology and ultra structure are needed to classify rhabdomyosarcoma and immunohistochemistry act only as an auxiliary. |
| first_indexed | 2024-04-11T18:27:51Z |
| format | Article |
| id | doaj.art-8f0cbed0a07e48deaeb3a8be00141cd5 |
| institution | Directory Open Access Journal |
| issn | 2039-7275 2039-7283 |
| language | English |
| last_indexed | 2024-04-11T18:27:51Z |
| publishDate | 2012-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-8f0cbed0a07e48deaeb3a8be00141cd52022-12-22T04:09:33ZengMDPI AGClinics and Practice2039-72752039-72832012-01-012110.4081/cp.2012.e17157Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysisMadhusudan Astekar0Rashmi Metgud1Priyanka Sharma2Gayatri Ramesh3Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan)Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan)Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan)Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur (Rajasthan)Rhabdomyosarcomas are among the most common soft-tissue tumors in children. These tumors are derived from mesenchymal tissue with a tendency toward myogenic differentiation that probably originates from immature and highly invasive satellite cells associated with the embryogenesis of skeletal muscle. Some of these tumors are associated with high rates of recurrence and metastasis. The diagnosis is made by microscopic analysis and auxiliary techniques such as immunohistochemistry, electron microscopy, cytogenetic analysis, and molecular biology. We report a case of 28- year-old man who presented with a painless progressive swelling of gingiva since 3 months, which was gradually increasing in size without any systemic symptoms or signs of any metastatic spread. An incisional biopsy was done and histopathology reported an alveolar variant of rhabdomyosarcoma. Immuno - histochemistry with panel of markers was done which showed positivity for CD99, vimentin and negative for desmin and myogenin. So the characteristic immunohistological expression was negative in present case. Hence we conclude that haematoxylin and eosin morphology and ultra structure are needed to classify rhabdomyosarcoma and immunohistochemistry act only as an auxiliary.https://www.clinicsandpractice.org/index.php/cp/article/view/429rhabdomyosarcomasoft-tissue tumorschildrenskeletal muscle neoplasmhead and neck tumorsexophytic growth. |
| spellingShingle | Madhusudan Astekar Rashmi Metgud Priyanka Sharma Gayatri Ramesh Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis Clinics and Practice rhabdomyosarcoma soft-tissue tumors children skeletal muscle neoplasm head and neck tumors exophytic growth. |
| title | Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis |
| title_full | Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis |
| title_fullStr | Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis |
| title_full_unstemmed | Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis |
| title_short | Oral alveolar rhabdomyosarcoma: a case report with immunohistochemical analysis |
| title_sort | oral alveolar rhabdomyosarcoma a case report with immunohistochemical analysis |
| topic | rhabdomyosarcoma soft-tissue tumors children skeletal muscle neoplasm head and neck tumors exophytic growth. |
| url | https://www.clinicsandpractice.org/index.php/cp/article/view/429 |
| work_keys_str_mv | AT madhusudanastekar oralalveolarrhabdomyosarcomaacasereportwithimmunohistochemicalanalysis AT rashmimetgud oralalveolarrhabdomyosarcomaacasereportwithimmunohistochemicalanalysis AT priyankasharma oralalveolarrhabdomyosarcomaacasereportwithimmunohistochemicalanalysis AT gayatriramesh oralalveolarrhabdomyosarcomaacasereportwithimmunohistochemicalanalysis |