Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation.
Dilated cardiomyopathy (DCM) is the most common myocardial disease. It not only leads to systolic dysfunction but also diastolic deficiency. We sought to investigate the effect of idiopathic and ischemic DCM on the intraventricular fluid dynamics and myocardial wall mechanics using a 2D axisymmetric...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3692440?pdf=render |
| _version_ | 1818925334747152384 |
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| author | Bee Ting Chan Noor Azuan Abu Osman Einly Lim Kok Han Chee Yang Faridah Abdul Aziz Amr Al Abed Nigel H Lovell Socrates Dokos |
| author_facet | Bee Ting Chan Noor Azuan Abu Osman Einly Lim Kok Han Chee Yang Faridah Abdul Aziz Amr Al Abed Nigel H Lovell Socrates Dokos |
| author_sort | Bee Ting Chan |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is the most common myocardial disease. It not only leads to systolic dysfunction but also diastolic deficiency. We sought to investigate the effect of idiopathic and ischemic DCM on the intraventricular fluid dynamics and myocardial wall mechanics using a 2D axisymmetrical fluid structure interaction model. In addition, we also studied the individual effect of parameters related to DCM, i.e. peak E-wave velocity, end systolic volume, wall compliance and sphericity index on several important fluid dynamics and myocardial wall mechanics variables during ventricular filling. Intraventricular fluid dynamics and myocardial wall deformation are significantly impaired under DCM conditions, being demonstrated by low vortex intensity, low flow propagation velocity, low intraventricular pressure difference (IVPD) and strain rates, and high-end diastolic pressure and wall stress. Our sensitivity analysis results showed that flow propagation velocity substantially decreases with an increase in wall stiffness, and is relatively independent of preload at low-peak E-wave velocity. Early IVPD is mainly affected by the rate of change of the early filling velocity and end systolic volume which changes the ventriculo:annular ratio. Regional strain rate, on the other hand, is significantly correlated with regional stiffness, and therefore forms a useful indicator for myocardial regional ischemia. The sensitivity analysis results enhance our understanding of the mechanisms leading to clinically observable changes in patients with DCM. |
| first_indexed | 2024-12-20T02:39:35Z |
| format | Article |
| id | doaj.art-8f0cc77319564c55b87c8bfb0c385d7f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T02:39:35Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8f0cc77319564c55b87c8bfb0c385d7f2022-12-21T19:56:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6709710.1371/journal.pone.0067097Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation.Bee Ting ChanNoor Azuan Abu OsmanEinly LimKok Han CheeYang Faridah Abdul AzizAmr Al AbedNigel H LovellSocrates DokosDilated cardiomyopathy (DCM) is the most common myocardial disease. It not only leads to systolic dysfunction but also diastolic deficiency. We sought to investigate the effect of idiopathic and ischemic DCM on the intraventricular fluid dynamics and myocardial wall mechanics using a 2D axisymmetrical fluid structure interaction model. In addition, we also studied the individual effect of parameters related to DCM, i.e. peak E-wave velocity, end systolic volume, wall compliance and sphericity index on several important fluid dynamics and myocardial wall mechanics variables during ventricular filling. Intraventricular fluid dynamics and myocardial wall deformation are significantly impaired under DCM conditions, being demonstrated by low vortex intensity, low flow propagation velocity, low intraventricular pressure difference (IVPD) and strain rates, and high-end diastolic pressure and wall stress. Our sensitivity analysis results showed that flow propagation velocity substantially decreases with an increase in wall stiffness, and is relatively independent of preload at low-peak E-wave velocity. Early IVPD is mainly affected by the rate of change of the early filling velocity and end systolic volume which changes the ventriculo:annular ratio. Regional strain rate, on the other hand, is significantly correlated with regional stiffness, and therefore forms a useful indicator for myocardial regional ischemia. The sensitivity analysis results enhance our understanding of the mechanisms leading to clinically observable changes in patients with DCM.http://europepmc.org/articles/PMC3692440?pdf=render |
| spellingShingle | Bee Ting Chan Noor Azuan Abu Osman Einly Lim Kok Han Chee Yang Faridah Abdul Aziz Amr Al Abed Nigel H Lovell Socrates Dokos Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. PLoS ONE |
| title | Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. |
| title_full | Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. |
| title_fullStr | Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. |
| title_full_unstemmed | Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. |
| title_short | Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. |
| title_sort | sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation |
| url | http://europepmc.org/articles/PMC3692440?pdf=render |
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