Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives. The BF fram...

Full description

Bibliographic Details
Main Authors:	Gaia Fancellu, Karam Chand, Daniel Tomás, Elisabetta Orlandini, Luca Piemontese, Diana F. Silva, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	alzheimer’s disease multi-target drugs tacrine-benzofuran hybrids ache inhibitors metal chelators
Online Access:	http://dx.doi.org/10.1080/14756366.2019.1689237

Similar Items

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease
by: Wen-Yu Wu, et al.
Published: (2017-01-01)

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
by: Rajeshwari Rajeshwari, et al.
Published: (2019-02-01)

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease
by: Yingbo Fu, et al.
Published: (2016-10-01)

Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
by: Maja Przybyłowska, et al.
Published: (2022-12-01)

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
by: Ling-Yi Kong, et al.
Published: (2010-11-01)

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy
by: Youssef Dgachi, et al.
Published: (2019-01-01)

Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
by: Maria Kozurkova, et al.
Published: (2011-02-01)

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
by: Yiting Luo, et al.
Published: (2011-02-01)

Design, Synthesis and Molecular Modeling Study of Radiotracers Based on Tacrine and Its Derivatives for Study on Alzheimer’s Disease and Its Early Diagnosis
by: Przemysław Koźmiński, et al.
Published: (2024-03-01)

Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives
by: Salih Ökten, et al.
Published: (2019-10-01)

Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer’s disease
by: Huali Yang, et al.
Published: (2023-12-01)

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy
by: Eva Ramos, et al.
Published: (2019-04-01)

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles
by: Sara Silva, et al.
Published: (2020-10-01)

Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
by: Jie Zhu, et al.
Published: (2018-01-01)

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment
by: Jan Korabecny, et al.
Published: (2015-12-01)

New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones
by: Natalia A. Elkina, et al.
Published: (2022-10-01)

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
by: Zofia Chrienova, et al.
Published: (2022-12-01)

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation
by: Chandran Remya, et al.
Published: (2021-01-01)

Participation of cAMP in tacrine-induced gastric smooth muscle relaxation
by: Prissadova Natalia, et al.
Published: (2011-02-01)

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test
by: Jan Misik, et al.
Published: (2015-12-01)

Comparative X-Ray study of galantamine and tacrine on the evacuatory function of rat gastrointestinal tract
by: Kristev Athanas, et al.
Published: (2008-03-01)

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
by: Yao Chen, et al.
Published: (2018-01-01)

Synthesis of novel Schiff base derivatives of tacrine and investigation of their acetylcholinesterase inhibition potency
by: Elif Koyuncu, et al.
Published: (2019-05-01)

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
by: Luca Piemontese, et al.
Published: (2018-01-01)

Tacrine-induced tachyphylaxis in gastric smooth muscles
by: Prissadova Natalia, et al.
Published: (2012-12-01)

Structural, harmonic force field and vibrational studies of cholinesterase inhibitor tacrine used for treatment of Alzheimer's disease
by: Tom Sundius, et al.
Published: (2023-06-01)

The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs
by: Jan Bures, et al.
Published: (2024-11-01)

Molecular Dynamics Revealing a Detour-Forward Release Mechanism of Tacrine: Implication for the Specific Binding Characteristics in Butyrylcholinesterase
by: Zhiyang Zhang, et al.
Published: (2020-08-01)

Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation
by: Pouramiri Behjat, et al.
Published: (2020-01-01)

Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer′s Disease Therapy
by: Agnieszka Zagórska, et al.
Published: (2020-07-01)

Exploring the Multi–Target Neuroprotective Chemical Space of Benzofuran Scaffolds: A New Strategy in Drug Development for Alzheimer’s Disease
by: Jaime R. Cabrera-Pardo, et al.
Published: (2020-01-01)

<b>Titanium-induced synthesis of benzofurans</b>
by: N.D. Jumbam, et al.
Published: (2011-04-01)

Protective Effects of Red Ginseng Against Tacrine-Induced Hepatotoxicity: An Integrated Approach with Network Pharmacology and Experimental Validation
by: Kim BJ, et al.
Published: (2024-02-01)

Methyl 5-(1-benzofuran-2-yl)isoxazole-3-carboxylate
by: Gamal A. El-Hiti, et al.
Published: (2017-12-01)

Anti-Cancer Effect of Tacrine-Coumarin Derivatives on Diverse Human and Mouse Cancer Cell Lines
by: Zuzana Solárová, et al.
Published: (2018-12-01)

A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions
by: Luciana Cicco, et al.
Published: (2024-03-01)

Benzofuran-Tetrahydrodipyrazolopyridine Hybrids: Novel Compounds for Potential Lung Cancer Treatment
by: İzgördü Hüseyin, et al.
Published: (2024-01-01)

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer’s Disease
by: Xiuyuan Wu, et al.
Published: (2024-04-01)

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
by: Jana Janockova, et al.
Published: (2019-01-01)

Crystal structure of 2-(5-methoxy-1-benzofuran-3-yl)acetic acid
by: Ramakrishna Gowda, et al.
Published: (2015-12-01)