The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease across the world. Due to the high prevalence of NAFLD, some patients tend to use herbal medicines for its treatment. The aim of the present study was to evaluate the effects of curcumin pill on NAFLD. Met...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2019-11-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/12247 |
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| author | Bahram Pakzad Arash Hedayat Mehdi Ahmadian Amin Bagheri-Ghalehsalimi Mojtaba Akbari |
| author_facet | Bahram Pakzad Arash Hedayat Mehdi Ahmadian Amin Bagheri-Ghalehsalimi Mojtaba Akbari |
| author_sort | Bahram Pakzad |
| collection | DOAJ |
| description | Background: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease across the world. Due to the high prevalence of NAFLD, some patients tend to use herbal medicines for its treatment. The aim of the present study was to evaluate the effects of curcumin pill on NAFLD.
Methods: In this clinical trial study, 100 patients with NAFLD were enrolled. Then, their height, weight, and body mass index were measured, and liver function tests and liver ultrasound were performed, too. The patients were then divided into two groups of case and control, and received curcumin and placebo for eight weeks, respectively. Before and after intervention, fasting blood sugar (FBS), lipid profile levels [including total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], human C-reactive protein (hCRP) level, and liver markers such as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) were measured and recorded again. Data were analyzed and compared between two groups using SPSS software.
Findings: There was no significant difference between the two groups in terms of gender, age, clinical features, total cholesterol, triglyceride, LDL, HDL, FBS, liver function markers such as ALP, ALT, and AST, and hCRP, and fatty liver grade at the onset of the study (P > 0.050). However, the level of ALT, AST, and hCRP significantly reduced in the case group after the intervention (P < 0.001).
Conclusion: According to the results of the present study, it seems that curcumin can be recommended for appropriate treatment of NAFLD. |
| first_indexed | 2024-03-12T10:14:56Z |
| format | Article |
| id | doaj.art-8f0f226eeb014b348db6b90b46e8f92e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T10:14:56Z |
| publishDate | 2019-11-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-8f0f226eeb014b348db6b90b46e8f92e2023-09-02T10:32:48ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-11-013753894394910.22122/jims.v37i538.122473479The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial StudyBahram Pakzad0Arash Hedayat1Mehdi Ahmadian2Amin Bagheri-Ghalehsalimi3Mojtaba Akbari4Assistant Professor, Department of Internal Medicine, School of Medicine AND Isfahan Bone Metabolic Disorders Research Center, Isfahan University of Medical Sciences, Isfahan IranResident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGastroenterologist, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranResident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Science, Isfahan, IranBackground: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease across the world. Due to the high prevalence of NAFLD, some patients tend to use herbal medicines for its treatment. The aim of the present study was to evaluate the effects of curcumin pill on NAFLD. Methods: In this clinical trial study, 100 patients with NAFLD were enrolled. Then, their height, weight, and body mass index were measured, and liver function tests and liver ultrasound were performed, too. The patients were then divided into two groups of case and control, and received curcumin and placebo for eight weeks, respectively. Before and after intervention, fasting blood sugar (FBS), lipid profile levels [including total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], human C-reactive protein (hCRP) level, and liver markers such as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) were measured and recorded again. Data were analyzed and compared between two groups using SPSS software. Findings: There was no significant difference between the two groups in terms of gender, age, clinical features, total cholesterol, triglyceride, LDL, HDL, FBS, liver function markers such as ALP, ALT, and AST, and hCRP, and fatty liver grade at the onset of the study (P > 0.050). However, the level of ALT, AST, and hCRP significantly reduced in the case group after the intervention (P < 0.001). Conclusion: According to the results of the present study, it seems that curcumin can be recommended for appropriate treatment of NAFLD.http://jims.mui.ac.ir/index.php/jims/article/view/12247curcuminnon-alcoholic fatty liver diseasetreatment |
| spellingShingle | Bahram Pakzad Arash Hedayat Mehdi Ahmadian Amin Bagheri-Ghalehsalimi Mojtaba Akbari The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study مجله دانشکده پزشکی اصفهان curcumin non-alcoholic fatty liver disease treatment |
| title | The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study |
| title_full | The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study |
| title_fullStr | The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study |
| title_full_unstemmed | The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study |
| title_short | The Effect of Curcumin Pill in Treatment of Non-alcoholic Fatty Liver Disease: A Clinical Trial Study |
| title_sort | effect of curcumin pill in treatment of non alcoholic fatty liver disease a clinical trial study |
| topic | curcumin non-alcoholic fatty liver disease treatment |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/12247 |
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