The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis
Ying Zhang,* Sainan Liu,* Qi Miao, Xu Zhang, He Wei, Shuang Feng, Xiaofei Li The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofei Li, Transplantation and H...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-03-01
|
| Series: | Psychology Research and Behavior Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-heterogeneity-of-symptom-burden-and-fear-of-progression-among-kidn-peer-reviewed-fulltext-article-PRBM |
| _version_ | 1797257134887403520 |
|---|---|
| author | Zhang Y Liu S Miao Q Zhang X Wei H Feng S Li X |
| author_facet | Zhang Y Liu S Miao Q Zhang X Wei H Feng S Li X |
| author_sort | Zhang Y |
| collection | DOAJ |
| description | Ying Zhang,* Sainan Liu,* Qi Miao, Xu Zhang, He Wei, Shuang Feng, Xiaofei Li The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofei Li, Transplantation and Hepatobiliary Department, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China, Tel +15940564748, Email lixiaofei0603@aliyun.comPurpose: Kidney transplant recipients (KTRs) may experience symptoms that increase their fear of progression (FoP), but a dearth of research examines the issue from a patient-centered perspective. Our study aimed to first determine the category of symptom burden, then to explore the differences in characteristics of patients in different subgroups, and finally to analyze the impact of symptom subgroup on FoP.Patients and Methods: Sociodemographic and Clinical Characteristics, Symptom Experience Scale, and Fear of Progression Questionnaire-Short Form were used. Latent class analysis was used to group KTRs according to the occurrence of symptoms. We used multivariate logistic regression to analyze the predictors of different subgroups. The differences in FoP among symptom burden subgroups were analyzed by hierarchical multiple regression.Results: Three subgroups were identified, designated all-high (20.5%), moderate (39.9%), and all-low (39.6%) according to their symptom occurrence. Multivariate logistic regression showed that gender, post-transplant time, per capita monthly income, and hyperuricemia were the factors that distinguished and predicted the all-high subgroup (P < 0.05). Hierarchical multiple regression showed that symptom burden had a significant effect on FoP (class1 vs class3: β = 0.327, P < 0.001; class2 vs class3: β = 0.104, P = 0.046), explaining the 8.0% variance of FoP (ΔR2 = 0.080).Conclusion: KTRs generally experience moderate or low symptom burden, and symptom burden is an influencing factor in FoP. Identifying the traits of KTRs with high symptom burden can help clinicians develop targeted management strategies and ease FoP of KTRs.Keywords: kidney transplant, symptom burden, fear of progression, latent class analysis |
| first_indexed | 2024-04-24T22:32:49Z |
| format | Article |
| id | doaj.art-8f0f65c7290c40c7b45e7b6be1bc8a10 |
| institution | Directory Open Access Journal |
| issn | 1179-1578 |
| language | English |
| last_indexed | 2024-04-24T22:32:49Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Psychology Research and Behavior Management |
| spelling | doaj.art-8f0f65c7290c40c7b45e7b6be1bc8a102024-03-19T17:12:18ZengDove Medical PressPsychology Research and Behavior Management1179-15782024-03-01Volume 171205121991330The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class AnalysisZhang YLiu SMiao QZhang XWei HFeng SLi XYing Zhang,* Sainan Liu,* Qi Miao, Xu Zhang, He Wei, Shuang Feng, Xiaofei Li The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofei Li, Transplantation and Hepatobiliary Department, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China, Tel +15940564748, Email lixiaofei0603@aliyun.comPurpose: Kidney transplant recipients (KTRs) may experience symptoms that increase their fear of progression (FoP), but a dearth of research examines the issue from a patient-centered perspective. Our study aimed to first determine the category of symptom burden, then to explore the differences in characteristics of patients in different subgroups, and finally to analyze the impact of symptom subgroup on FoP.Patients and Methods: Sociodemographic and Clinical Characteristics, Symptom Experience Scale, and Fear of Progression Questionnaire-Short Form were used. Latent class analysis was used to group KTRs according to the occurrence of symptoms. We used multivariate logistic regression to analyze the predictors of different subgroups. The differences in FoP among symptom burden subgroups were analyzed by hierarchical multiple regression.Results: Three subgroups were identified, designated all-high (20.5%), moderate (39.9%), and all-low (39.6%) according to their symptom occurrence. Multivariate logistic regression showed that gender, post-transplant time, per capita monthly income, and hyperuricemia were the factors that distinguished and predicted the all-high subgroup (P < 0.05). Hierarchical multiple regression showed that symptom burden had a significant effect on FoP (class1 vs class3: β = 0.327, P < 0.001; class2 vs class3: β = 0.104, P = 0.046), explaining the 8.0% variance of FoP (ΔR2 = 0.080).Conclusion: KTRs generally experience moderate or low symptom burden, and symptom burden is an influencing factor in FoP. Identifying the traits of KTRs with high symptom burden can help clinicians develop targeted management strategies and ease FoP of KTRs.Keywords: kidney transplant, symptom burden, fear of progression, latent class analysishttps://www.dovepress.com/the-heterogeneity-of-symptom-burden-and-fear-of-progression-among-kidn-peer-reviewed-fulltext-article-PRBMkidney transplantsymptom burdenfear of progressionlatent class analysis |
| spellingShingle | Zhang Y Liu S Miao Q Zhang X Wei H Feng S Li X The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis Psychology Research and Behavior Management kidney transplant symptom burden fear of progression latent class analysis |
| title | The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis |
| title_full | The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis |
| title_fullStr | The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis |
| title_full_unstemmed | The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis |
| title_short | The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis |
| title_sort | heterogeneity of symptom burden and fear of progression among kidney transplant recipients a latent class analysis |
| topic | kidney transplant symptom burden fear of progression latent class analysis |
| url | https://www.dovepress.com/the-heterogeneity-of-symptom-burden-and-fear-of-progression-among-kidn-peer-reviewed-fulltext-article-PRBM |
| work_keys_str_mv | AT zhangy theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT lius theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT miaoq theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT zhangx theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT weih theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT fengs theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT lix theheterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT zhangy heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT lius heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT miaoq heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT zhangx heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT weih heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT fengs heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis AT lix heterogeneityofsymptomburdenandfearofprogressionamongkidneytransplantrecipientsalatentclassanalysis |