The metabolic switch can be activated in a recombinant strain of Streptomyces lividans by a low oxygen transfer rate in shake flasks

The metabolic switch can be activated in a recombinant strain of Streptomyces lividans by a low oxygen transfer rate in shake flasks

Abstract Background In Streptomyces, understanding the switch from primary to secondary metabolism is important for maximizing the production of secondary metabolites such as antibiotics, as well as for optimizing recombinant glycoprotein production. Differences in Streptomyces lividans bacterial ag...

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Bibliographic Details
Main Authors: Ramsés A. Gamboa-Suasnavart, Norma A. Valdez-Cruz, Gerardo Gaytan-Ortega, Greta I. Reynoso-Cereceda, Daniel Cabrera-Santos, Lorena López-Griego, Wolf Klöckner, Jochen Büchs, Mauricio A. Trujillo-Roldán
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Microbial Cell Factories
Subjects:
Metabolic switch
Orbital shaking
Streptomyces lividans
Oxygen transfer rate
Recombinant glycoproteins
Shaken bioreactors
Online Access:http://link.springer.com/article/10.1186/s12934-018-1035-3

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