Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells

Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells

Abstract Antibody neutralization of cytomegalovirus (CMV) entry into diverse cell types is a key consideration for development of vaccines and immunotherapeutics. CMV entry into fibroblasts differs significantly from entry into epithelial or endothelial cells: fibroblast entry is mediated by gB and...

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Bibliographic Details
Main Authors: Ying Qi, Li He, Xiaohong Cui, Laura Hertel, Daniel C. Freed, Tong-Ming Fu, Lawrence M. Kauvar, Michael A. McVoy, Qiang Ruan
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Virology Journal
Subjects:
Cytomegalovirus
Antibodies
Neutralization
Endothelial
Epithelial
Entry mechanisms
Online Access:http://link.springer.com/article/10.1186/s12985-020-01320-2

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