Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy
As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels (e.g., amino acids, ketone bodies), in order to sustain constant contractile function. While the heal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.570421/full |
| _version_ | 1818178734681751552 |
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| author | Amanda A. Greenwell Amanda A. Greenwell Amanda A. Greenwell Keshav Gopal Keshav Gopal Keshav Gopal John R. Ussher John R. Ussher John R. Ussher |
| author_facet | Amanda A. Greenwell Amanda A. Greenwell Amanda A. Greenwell Keshav Gopal Keshav Gopal Keshav Gopal John R. Ussher John R. Ussher John R. Ussher |
| author_sort | Amanda A. Greenwell |
| collection | DOAJ |
| description | As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels (e.g., amino acids, ketone bodies), in order to sustain constant contractile function. While the healthy mature heart acts omnivorously and is highly flexible in its ability to utilize the numerous fuel sources delivered to it through its coronary circulation, the heart’s ability to produce ATP from these fuel sources becomes perturbed in numerous cardiovascular disorders. This includes ischemic heart disease and myocardial infarction, as well as in various cardiomyopathies that often precede the development of overt heart failure. We herein will provide an overview of myocardial energy metabolism in the healthy heart, while describing the numerous perturbations that take place in various non-ischemic cardiomyopathies such as hypertrophic cardiomyopathy, diabetic cardiomyopathy, arrhythmogenic cardiomyopathy, and the cardiomyopathy associated with the rare genetic disease, Barth Syndrome. Based on preclinical evidence where optimizing myocardial energy metabolism has been shown to attenuate cardiac dysfunction, we will discuss the feasibility of myocardial energetics optimization as an approach to treat the cardiac pathology associated with these various non-ischemic cardiomyopathies. |
| first_indexed | 2024-12-11T20:52:41Z |
| format | Article |
| id | doaj.art-8f10b6ee74ef4a6e88a0f101c1023524 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T20:52:41Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8f10b6ee74ef4a6e88a0f101c10235242022-12-22T00:51:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.570421570421Myocardial Energy Metabolism in Non-ischemic CardiomyopathyAmanda A. Greenwell0Amanda A. Greenwell1Amanda A. Greenwell2Keshav Gopal3Keshav Gopal4Keshav Gopal5John R. Ussher6John R. Ussher7John R. Ussher8Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, CanadaAlberta Diabetes Institute, University of Alberta, Edmonton, AB, CanadaMazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, CanadaFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, CanadaAlberta Diabetes Institute, University of Alberta, Edmonton, AB, CanadaMazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, CanadaFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, CanadaAlberta Diabetes Institute, University of Alberta, Edmonton, AB, CanadaMazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, CanadaAs the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels (e.g., amino acids, ketone bodies), in order to sustain constant contractile function. While the healthy mature heart acts omnivorously and is highly flexible in its ability to utilize the numerous fuel sources delivered to it through its coronary circulation, the heart’s ability to produce ATP from these fuel sources becomes perturbed in numerous cardiovascular disorders. This includes ischemic heart disease and myocardial infarction, as well as in various cardiomyopathies that often precede the development of overt heart failure. We herein will provide an overview of myocardial energy metabolism in the healthy heart, while describing the numerous perturbations that take place in various non-ischemic cardiomyopathies such as hypertrophic cardiomyopathy, diabetic cardiomyopathy, arrhythmogenic cardiomyopathy, and the cardiomyopathy associated with the rare genetic disease, Barth Syndrome. Based on preclinical evidence where optimizing myocardial energy metabolism has been shown to attenuate cardiac dysfunction, we will discuss the feasibility of myocardial energetics optimization as an approach to treat the cardiac pathology associated with these various non-ischemic cardiomyopathies.https://www.frontiersin.org/article/10.3389/fphys.2020.570421/fullenergy metabolismcardiomyopathycardiac functionglucose oxidationfatty acid oxidation |
| spellingShingle | Amanda A. Greenwell Amanda A. Greenwell Amanda A. Greenwell Keshav Gopal Keshav Gopal Keshav Gopal John R. Ussher John R. Ussher John R. Ussher Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy Frontiers in Physiology energy metabolism cardiomyopathy cardiac function glucose oxidation fatty acid oxidation |
| title | Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy |
| title_full | Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy |
| title_fullStr | Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy |
| title_full_unstemmed | Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy |
| title_short | Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy |
| title_sort | myocardial energy metabolism in non ischemic cardiomyopathy |
| topic | energy metabolism cardiomyopathy cardiac function glucose oxidation fatty acid oxidation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.570421/full |
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