Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer
Abstract Background Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast canc...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-02-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-02944-8 |
| _version_ | 1797864505510723584 |
|---|---|
| author | Chi-Chang Chang Chia-Chang Hsu Teng-Hung Yu Wei-Chin Hung Shyh-Ming Kuo Chia-Chi Chen Cheng-Ching Wu Fu-Mei Chung Yau-Jiunn Lee Ching-Ting Wei |
| author_facet | Chi-Chang Chang Chia-Chang Hsu Teng-Hung Yu Wei-Chin Hung Shyh-Ming Kuo Chia-Chi Chen Cheng-Ching Wu Fu-Mei Chung Yau-Jiunn Lee Ching-Ting Wei |
| author_sort | Chi-Chang Chang |
| collection | DOAJ |
| description | Abstract Background Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. Method A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. Result The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. Conclusions Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer. |
| first_indexed | 2024-04-09T22:54:02Z |
| format | Article |
| id | doaj.art-8f10c690eb014cb8b3bded9fd75a3c72 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-09T22:54:02Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-8f10c690eb014cb8b3bded9fd75a3c722023-03-22T11:24:15ZengBMCWorld Journal of Surgical Oncology1477-78192023-02-0121111010.1186/s12957-023-02944-8Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancerChi-Chang Chang0Chia-Chang Hsu1Teng-Hung Yu2Wei-Chin Hung3Shyh-Ming Kuo4Chia-Chi Chen5Cheng-Ching Wu6Fu-Mei Chung7Yau-Jiunn Lee8Ching-Ting Wei9Department of Obstetrics & Gynecology, E-Da Hospital/E-Da Dachang HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da HospitalDivision of Cardiology, Department of Internal Medicine, E-Da HospitalDivision of Cardiology, Department of Internal Medicine, E-Da HospitalDepartment of Biomedical Engineering, I-Shou UniversityDepartment of Pathology, E-Da HospitalDivision of Cardiology, Department of Internal Medicine, E-Da HospitalDivision of Cardiology, Department of Internal Medicine, E-Da HospitalLee’s Endocrinologic ClinicThe School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou UniversityAbstract Background Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. Method A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. Result The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. Conclusions Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer.https://doi.org/10.1186/s12957-023-02944-8Liver-type fatty acid-binding proteinConcentrationsExpressionBreast cancer |
| spellingShingle | Chi-Chang Chang Chia-Chang Hsu Teng-Hung Yu Wei-Chin Hung Shyh-Ming Kuo Chia-Chi Chen Cheng-Ching Wu Fu-Mei Chung Yau-Jiunn Lee Ching-Ting Wei Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer World Journal of Surgical Oncology Liver-type fatty acid-binding protein Concentrations Expression Breast cancer |
| title | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
| title_full | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
| title_fullStr | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
| title_full_unstemmed | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
| title_short | Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer |
| title_sort | plasma levels and tissue expression of liver type fatty acid binding protein in patients with breast cancer |
| topic | Liver-type fatty acid-binding protein Concentrations Expression Breast cancer |
| url | https://doi.org/10.1186/s12957-023-02944-8 |
| work_keys_str_mv | AT chichangchang plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chiachanghsu plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT tenghungyu plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT weichinhung plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT shyhmingkuo plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chiachichen plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chengchingwu plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT fumeichung plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT yaujiunnlee plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer AT chingtingwei plasmalevelsandtissueexpressionoflivertypefattyacidbindingproteininpatientswithbreastcancer |