Understanding and Exploiting Phage–Host Interactions
Initially described a century ago by William Twort and Felix d’Herelle, bacteriophages are bacterial viruses found ubiquitously in nature, located wherever their host cells are present. Translated literally, bacteriophage (phage) means ‘bacteria eater’. Phages interact...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/6/567 |
| _version_ | 1828420929449885696 |
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| author | Edel Stone Katrina Campbell Irene Grant Olivia McAuliffe |
| author_facet | Edel Stone Katrina Campbell Irene Grant Olivia McAuliffe |
| author_sort | Edel Stone |
| collection | DOAJ |
| description | Initially described a century ago by William Twort and Felix d’Herelle, bacteriophages are bacterial viruses found ubiquitously in nature, located wherever their host cells are present. Translated literally, bacteriophage (phage) means ‘bacteria eater’. Phages interact and infect specific bacteria while not affecting other bacteria or cell lines of other organisms. Due to the specificity of these phage−host interactions, the relationship between phages and their host cells has been the topic of much research. The advances in phage biology research have led to the exploitation of these phage−host interactions and the application of phages in the agricultural and food industry. Phages may provide an alternative to the use of antibiotics, as it is well known that the emergence of antibiotic-resistant bacterial infections has become an epidemic in clinical settings. In agriculture, pre-harvest and/or post-harvest application of phages to crops may prevent the colonisation of bacteria that are detrimental to plant or human health. In addition, the abundance of data generated from genome sequencing has allowed the development of phage-derived bacterial detection systems of foodborne pathogens. This review aims to outline the specific interactions between phages and their host and how these interactions may be exploited and applied in the food industry. |
| first_indexed | 2024-12-10T15:21:36Z |
| format | Article |
| id | doaj.art-8f112dd5a7034230b229f5acb5b7d774 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T15:21:36Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8f112dd5a7034230b229f5acb5b7d7742022-12-22T01:43:40ZengMDPI AGViruses1999-49152019-06-0111656710.3390/v11060567v11060567Understanding and Exploiting Phage–Host InteractionsEdel Stone0Katrina Campbell1Irene Grant2Olivia McAuliffe3Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Cork, IrelandInstitute for Global Food Security, School of Biological Sciences, Queen’s University, Belfast, 19 Chlorine Gardens, BT9 5DL Belfast, UKInstitute for Global Food Security, School of Biological Sciences, Queen’s University, Belfast, 19 Chlorine Gardens, BT9 5DL Belfast, UKTeagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Cork, IrelandInitially described a century ago by William Twort and Felix d’Herelle, bacteriophages are bacterial viruses found ubiquitously in nature, located wherever their host cells are present. Translated literally, bacteriophage (phage) means ‘bacteria eater’. Phages interact and infect specific bacteria while not affecting other bacteria or cell lines of other organisms. Due to the specificity of these phage−host interactions, the relationship between phages and their host cells has been the topic of much research. The advances in phage biology research have led to the exploitation of these phage−host interactions and the application of phages in the agricultural and food industry. Phages may provide an alternative to the use of antibiotics, as it is well known that the emergence of antibiotic-resistant bacterial infections has become an epidemic in clinical settings. In agriculture, pre-harvest and/or post-harvest application of phages to crops may prevent the colonisation of bacteria that are detrimental to plant or human health. In addition, the abundance of data generated from genome sequencing has allowed the development of phage-derived bacterial detection systems of foodborne pathogens. This review aims to outline the specific interactions between phages and their host and how these interactions may be exploited and applied in the food industry.https://www.mdpi.com/1999-4915/11/6/567bacteriophagedetectionbiosensorfood-safetyagriculturereceptor binding proteinendolysinphage–host interactions |
| spellingShingle | Edel Stone Katrina Campbell Irene Grant Olivia McAuliffe Understanding and Exploiting Phage–Host Interactions Viruses bacteriophage detection biosensor food-safety agriculture receptor binding protein endolysin phage–host interactions |
| title | Understanding and Exploiting Phage–Host Interactions |
| title_full | Understanding and Exploiting Phage–Host Interactions |
| title_fullStr | Understanding and Exploiting Phage–Host Interactions |
| title_full_unstemmed | Understanding and Exploiting Phage–Host Interactions |
| title_short | Understanding and Exploiting Phage–Host Interactions |
| title_sort | understanding and exploiting phage host interactions |
| topic | bacteriophage detection biosensor food-safety agriculture receptor binding protein endolysin phage–host interactions |
| url | https://www.mdpi.com/1999-4915/11/6/567 |
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